High serum levels of galectins 1 and 4 in osteoarthritis patients.
Cartilage
ECM
Glycans
Joint
Journal
Clinical biochemistry
ISSN: 1873-2933
Titre abrégé: Clin Biochem
Pays: United States
ID NLM: 0133660
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
04
09
2022
revised:
14
02
2023
accepted:
24
02
2023
medline:
22
5
2023
pubmed:
2
3
2023
entrez:
1
3
2023
Statut:
ppublish
Résumé
Although immunostaining of galectins is associated with cartilage damage, the serum levels of these lectins in osteoarthritis (OA) are not fully understood. Therefore, we evaluate the concentrations of galectins-1, 3, 4, and 7 in patients with osteoarthritis and correlate them with clinical parameters. This cross-sectional study involved 60 osteoarthritis patients and 43 healthy volunteers, who had serum samples collected for galectins titration by Enzyme-Linked Immunosorbent Assay (ELISA). Our finds showed that the median values of gal-1 and 4 serum levels in patients were statistically higher (13,990 and 969.1 pg/mL, respectively) than in healthy controls (1,798 and 519.5 pg/mL) with p < 0.001. Further, gal-1 expressed higher levels in patients who had joint edema at the time of collection with a median value of 14,970 pg/mL. Surprisingly, galectin-4 appears to be involved in the osteoarthritis inflammation process as the well-known galectin-1.
Sections du résumé
BACKGROUND
BACKGROUND
Although immunostaining of galectins is associated with cartilage damage, the serum levels of these lectins in osteoarthritis (OA) are not fully understood.
OBJECTIVE
OBJECTIVE
Therefore, we evaluate the concentrations of galectins-1, 3, 4, and 7 in patients with osteoarthritis and correlate them with clinical parameters.
METHODS
METHODS
This cross-sectional study involved 60 osteoarthritis patients and 43 healthy volunteers, who had serum samples collected for galectins titration by Enzyme-Linked Immunosorbent Assay (ELISA).
RESULTS
RESULTS
Our finds showed that the median values of gal-1 and 4 serum levels in patients were statistically higher (13,990 and 969.1 pg/mL, respectively) than in healthy controls (1,798 and 519.5 pg/mL) with p < 0.001. Further, gal-1 expressed higher levels in patients who had joint edema at the time of collection with a median value of 14,970 pg/mL.
CONCLUSION
CONCLUSIONS
Surprisingly, galectin-4 appears to be involved in the osteoarthritis inflammation process as the well-known galectin-1.
Identifiants
pubmed: 36858300
pii: S0009-9120(23)00040-1
doi: 10.1016/j.clinbiochem.2023.02.011
pii:
doi:
Substances chimiques
Galectin 1
0
1-nitrohydroxyphenyl-N-benzoylalanine
59921-69-6
Galectins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-15Informations de copyright
Copyright © 2023 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.