Legionella and mitochondria, an intriguing relationship.
Cell death
Cell-autonomous immunity
Inflammasomes
Legionella pneumophila
Metabolism
Mitochondria
Pyroptosis
mROS
Journal
International review of cell and molecular biology
ISSN: 1937-6448
Titre abrégé: Int Rev Cell Mol Biol
Pays: Netherlands
ID NLM: 101475846
Informations de publication
Date de publication:
2023
2023
Historique:
entrez:
1
3
2023
pubmed:
2
3
2023
medline:
4
3
2023
Statut:
ppublish
Résumé
Legionella pneumophila is the causative agent of Legionnaires' disease, a severe pneumonia. L. pneumophila injects via a type-IV-secretion-system (T4SS) more than 300 bacterial proteins into macrophages, its main host cell in humans. Certain of these bacterial effectors target organelles in the infected cell and hijack multiple processes to facilitate all steps of the intracellular life cycle of this pathogen. In this review, we discuss the interplay between L. pneumophila, an intracellular bacterium fully armed with virulence tools, and mitochondria, the extraordinary eukaryotic organelles playing prominent roles in cellular bioenergetics, cell-autonomous immunity and cell death. We present and discuss key findings concerning the multiple interactions of L. pneumophila with mitochondria during infection and the mechanisms employed by T4SS effectors that target mitochondrial functions to subvert infected cells.
Identifiants
pubmed: 36858656
pii: S1937-6448(22)00135-6
doi: 10.1016/bs.ircmb.2022.10.001
pii:
doi:
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-81Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.