A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals.

Animals Mice Drug Evaluation, Preclinical Nociceptors Pain Nematoda Potassium Channels, Tandem Pore Domain / antagonists & inhibitors

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
01 03 2023
Historique:
received: 11 08 2022
accepted: 15 02 2023
entrez: 1 3 2023
pubmed: 2 3 2023
medline: 4 3 2023
Statut: epublish

Résumé

By endowing light control of neuronal activity, optogenetics and photopharmacology are powerful methods notably used to probe the transmission of pain signals. However, costs, animal handling and ethical issues have reduced their dissemination and routine use. Here we report LAKI (Light Activated K

Identifiants

DOI: 10.1038/s41467-023-36806-4 PMID: 36859433 PMC: PMC9977718
pubmed: 36859433
doi: 10.1038/s41467-023-36806-4
pii: 10.1038/s41467-023-36806-4
pmc: PMC9977718
doi:

Substances chimiques

potassium channel protein TREK-1 0
Potassium Channels, Tandem Pore Domain 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1160

Informations de copyright

© 2023. The Author(s).

Références

J Med Chem. 2021 Nov 11;64(21):16282-16292
pubmed: 34662118
J Pain. 2013 Nov;14(11):1255-69
pubmed: 24035349
Prim Care. 2012 Sep;39(3):561-71
pubmed: 22958566
Pharmacol Ther. 2021 Jun;222:107784
pubmed: 33316286
Nat Biotechnol. 2014 Mar;32(3):274-8
pubmed: 24531797
Nat Methods. 2011 Jan;8(1):26-9
pubmed: 21191368
J Neurosci. 2009 Feb 25;29(8):2528-33
pubmed: 19244527
Genetics. 1974 May;77(1):71-94
pubmed: 4366476
Bioconjug Chem. 2021 Sep 15;32(9):1979-1983
pubmed: 34448572
Brain Res Bull. 2015 Oct;119(Pt A):73-9
pubmed: 26321392
Ocul Surf. 2017 Jul;15(3):404-437
pubmed: 28736339
Annu Rev Pharmacol Toxicol. 1980;20:441-62
pubmed: 7387124
Adv Exp Med Biol. 2011;704:323-39
pubmed: 21290304
Front Mol Neurosci. 2013 Mar 21;6:5
pubmed: 23518818
Nat Methods. 2012 Feb 19;9(4):396-402
pubmed: 22343342
Nat Chem Biol. 2019 Jun;15(6):623-631
pubmed: 31036923
ACS Chem Neurosci. 2015 May 20;6(5):701-7
pubmed: 25741856
Pain. 2018 Sep;159 Suppl 1:S65-S73
pubmed: 30113949
Nat Neurosci. 2004 Dec;7(12):1381-6
pubmed: 15558062
Pain. 2014 Sep;155(9):1861-1870
pubmed: 24973718
Protein Cell. 2020 Apr;11(4):239-250
pubmed: 31907794
Pain. 2017 Dec;158(12):2329-2339
pubmed: 28708765
Neuroscience. 2001;103(4):853-9
pubmed: 11301195
Nat Neurosci. 2008 Aug;11(8):916-22
pubmed: 18604203
ACS Cent Sci. 2019 Apr 24;5(4):607-618
pubmed: 31041380
Nat Neurosci. 2015 Sep;18(9):1213-25
pubmed: 26308982
Pain. 1988 Jan;32(1):77-88
pubmed: 3340425
Pain. 2020 Sep 1;161(9):1976-1982
pubmed: 32694387
Neurosci Lett. 2009 Apr 24;454(2):129-33
pubmed: 19429069
iScience. 2021 Aug 08;24(9):102961
pubmed: 34458705
Pain. 2008 Oct 31;139(3):681-687
pubmed: 18789837
Nat Med. 2010 Oct;16(10):1157-60
pubmed: 20871611
ACS Chem Biol. 2013 Aug 16;8(8):1841-51
pubmed: 23738709
Neuron. 2019 Jan 16;101(2):232-245.e6
pubmed: 30573346

Auteurs

Arnaud Landra-Willm (A)

Université Côte d'Azur, CNRS, INSERM, iBV, Nice, France.
Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France.
Fédération Hospitalo-Universitaire InovPain, Cote d'Azur University, University Hospital Center, Nice, Provence-Alpes-Côte d'Azur, France.

Ameya Karapurkar (A)

University of Maine Department of Chemistry, 178 Munson Rd., Orono, ME, 04473, USA.

Alexia Duveau (A)

Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.

Anne Amandine Chassot (AA)

Université Côte d'Azur, CNRS, INSERM, iBV, Nice, France.
Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France.
Fédération Hospitalo-Universitaire InovPain, Cote d'Azur University, University Hospital Center, Nice, Provence-Alpes-Côte d'Azur, France.

Lucille Esnault (L)

Univ Angers, Nantes Université, INSERM, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302, Angers, France.
ORCID: 0000-0001-9467-5217

Gerard Callejo (G)

Neurophysiology Laboratory, Department of Biomedicine, Medical School, Institute of Neurosciences, Universitat de Barcelona, c. Casanova 143, 08036, Barcelona, Spain.
Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), c. Villarroel 170, 08036, Barcelona, Spain.

Marion Bied (M)

Université Côte d'Azur, CNRS, INSERM, iBV, Nice, France.
Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France.
Fédération Hospitalo-Universitaire InovPain, Cote d'Azur University, University Hospital Center, Nice, Provence-Alpes-Côte d'Azur, France.

Stephanie Häfner (S)

Université Côte d'Azur, CNRS, INSERM, iBV, Nice, France.
Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France.
Fédération Hospitalo-Universitaire InovPain, Cote d'Azur University, University Hospital Center, Nice, Provence-Alpes-Côte d'Azur, France.

Florian Lesage (F)

Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France.
Fédération Hospitalo-Universitaire InovPain, Cote d'Azur University, University Hospital Center, Nice, Provence-Alpes-Côte d'Azur, France.
Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Labex ICST, Université Côte d'Azur, INSERM, Valbonne, France.
ORCID: 0000-0002-4406-7106

Brigitte Wdziekonski (B)

Université Côte d'Azur, CNRS, INSERM, iBV, Nice, France.
Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France.
Fédération Hospitalo-Universitaire InovPain, Cote d'Azur University, University Hospital Center, Nice, Provence-Alpes-Côte d'Azur, France.

Anne Baron (A)

Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France.
Fédération Hospitalo-Universitaire InovPain, Cote d'Azur University, University Hospital Center, Nice, Provence-Alpes-Côte d'Azur, France.
Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Labex ICST, Université Côte d'Azur, INSERM, Valbonne, France.

Pascal Fossat (P)

Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.
ORCID: 0000-0001-5117-0817

Laurent Marsollier (L)

Univ Angers, Nantes Université, INSERM, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302, Angers, France.
ORCID: 0000-0001-5497-5995

Xavier Gasull (X)

Neurophysiology Laboratory, Department of Biomedicine, Medical School, Institute of Neurosciences, Universitat de Barcelona, c. Casanova 143, 08036, Barcelona, Spain.
Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), c. Villarroel 170, 08036, Barcelona, Spain.
ORCID: 0000-0002-6154-8323

Eric Boué-Grabot (E)

Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.
ORCID: 0000-0003-2187-9037

Michael A Kienzler (MA)

University of Connecticut Department of Chemistry, 55 N. Eagleville Rd Storrs, Mansfield, CT, 06269, USA. michael.kienzler@uconn.edu.
ORCID: 0000-0002-4385-4650

Guillaume Sandoz (G)

Université Côte d'Azur, CNRS, INSERM, iBV, Nice, France. sandoz@unice.fr.
Laboratories of Excellence, Ion Channel Science and Therapeutics, Nice, France. sandoz@unice.fr.
Fédération Hospitalo-Universitaire InovPain, Cote d'Azur University, University Hospital Center, Nice, Provence-Alpes-Côte d'Azur, France. sandoz@unice.fr.
ORCID: 0000-0003-1251-0852

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A photoswitchable inhibitor of TREK channels...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A photoswitchable inhibitor of TREK channels...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › A photoswitchable inhibitor of TREK channels...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Nocicepteurs › A photoswitchable inhibitor of TREK channels...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › A photoswitchable inhibitor of TREK channels...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › A photoswitchable inhibitor of TREK channels...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques à pores à domaines en tandem › A photoswitchable inhibitor of TREK channels...