Single-Cell Genomics for Investigating Pathogenesis of Inflammatory Diseases.
autoimmune disease
chronic inflammatory disease
coronavirus disease 2019
mouse model
multi-organ atlas
single-cell genomics
Journal
Molecules and cells
ISSN: 0219-1032
Titre abrégé: Mol Cells
Pays: Korea (South)
ID NLM: 9610936
Informations de publication
Date de publication:
28 Feb 2023
28 Feb 2023
Historique:
received:
01
01
2023
revised:
23
01
2023
accepted:
24
01
2023
entrez:
1
3
2023
pubmed:
2
3
2023
medline:
4
3
2023
Statut:
ppublish
Résumé
Recent technical advances have enabled unbiased transcriptomic and epigenetic analysis of each cell, known as "single-cell analysis". Single-cell analysis has a variety of technical approaches to investigate the state of each cell, including mRNA levels (transcriptome), the immune repertoire (immune repertoire analysis), cell surface proteins (surface proteome analysis), chromatin accessibility (epigenome), and accordance with genome variants (eQTLs; expression quantitative trait loci). As an effective tool for investigating robust immune responses in coronavirus disease 2019 (COVID-19), many researchers performed single-cell analysis to capture the diverse, unbiased immune cell activation and differentiation. Despite challenges elucidating the complicated immune microenvironments of chronic inflammatory diseases using existing experimental methods, it is now possible to capture the simultaneous immune features of different cell types across inflamed tissues using various single-cell tools. In this review, we introduce patient-based and experimental mouse model research utilizing single-cell analyses in the field of chronic inflammatory diseases, as well as multi-organ atlas targeting immune cells.
Identifiants
pubmed: 36859476
pii: molcells.2023.0002
doi: 10.14348/molcells.2023.0002
pmc: PMC9982059
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120-129Références
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Nat Immunol. 2019 Jul;20(7):928-942
pubmed: 31061532
J Exp Med. 2020 Jun 1;217(6):
pubmed: 32251514
Science. 2022 May 13;376(6594):eabl4896
pubmed: 35549404
Nature. 2021 Sep;597(7878):709-714
pubmed: 34497421
Front Immunol. 2021 Nov 29;12:729040
pubmed: 34912329
Commun Biol. 2021 Dec 14;4(1):1395
pubmed: 34907325
Signal Transduct Target Ther. 2021 Sep 16;6(1):342
pubmed: 34531370
Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5430-5441
pubmed: 32094172
Nat Immunol. 2020 Sep;21(9):1107-1118
pubmed: 32788748
Nat Genet. 2022 Jun;54(6):817-826
pubmed: 35618845
Elife. 2017 Dec 05;6:
pubmed: 29206104
Nat Commun. 2022 Jan 21;13(1):440
pubmed: 35064122
Cell. 2019 Dec 12;179(7):1636-1646.e15
pubmed: 31787378
Sci Immunol. 2020 Aug 21;5(50):
pubmed: 32826341
Cell Rep. 2022 Nov 8;41(6):111606
pubmed: 36351407
J Immunol. 2013 Jun 15;190(12):5961-71
pubmed: 23677470
Mol Cells. 2019 Nov 30;42(11):747-754
pubmed: 31766832
Nat Med. 2021 May;27(5):904-916
pubmed: 33879890
Sci Immunol. 2020 Jul 10;5(49):
pubmed: 32651212
Nat Immunol. 2019 Aug;20(8):970-979
pubmed: 31235952
Nat Rev Dis Primers. 2017 Mar 30;3:17016
pubmed: 28358037
Innovation (Camb). 2022 Sep 13;3(5):100289
pubmed: 35879967
Nat Methods. 2017 Sep;14(9):865-868
pubmed: 28759029
J Exp Med. 2021 Sep 6;218(9):
pubmed: 34279540
Curr Pharm Des. 2015;21(18):2350-64
pubmed: 25777752
Nat Methods. 2021 Aug;18(8):881-892
pubmed: 34282327
Blood Adv. 2022 May 10;6(9):2791-2804
pubmed: 35015822
Nature. 2015 Jul 23;523(7561):486-90
pubmed: 26083756
Cell. 2021 Apr 1;184(7):1895-1913.e19
pubmed: 33657410
Nat Metab. 2022 Feb;4(2):284-299
pubmed: 35228745
Med (N Y). 2022 Jul 8;3(7):481-518.e14
pubmed: 35649411
Nat Cell Biol. 2021 Jun;23(6):620-630
pubmed: 34108657
Nat Commun. 2021 Aug 17;12(1):4977
pubmed: 34404786
Nature. 2021 Jun;594(7863):398-402
pubmed: 34012112
Nat Commun. 2020 Jan 14;11(1):247
pubmed: 31937773
Nat Rev Dis Primers. 2016 Jun 16;2:16039
pubmed: 27306639
Nature. 2021 Jul;595(7865):114-119
pubmed: 33915568
Nature. 2022 Jun;606(7912):120-128
pubmed: 35545678
JAMA. 2020 May 19;323(19):1945-1960
pubmed: 32427307
Front Immunol. 2021 Nov 22;12:760381
pubmed: 34880858
J Immunol. 2022 Jul 15;209(2):238-249
pubmed: 35705251
Science. 2022 Apr 8;376(6589):eabf3041
pubmed: 35389779
Nat Rev Immunol. 2011 Apr;11(4):251-63
pubmed: 21394103
Science. 2022 May 13;376(6594):eabl4290
pubmed: 35549429
Nat Commun. 2021 Mar 26;12(1):1921
pubmed: 33771991
Science. 2015 May 22;348(6237):910-4
pubmed: 25953818
Nat Commun. 2022 Jun 16;13(1):3466
pubmed: 35710908
Nature. 2003 Nov 27;426(6965):454-60
pubmed: 14647385
Nat Cell Biol. 2007 Jan;9(1):2-6
pubmed: 17199124
Nat Immunol. 2018 Jul;19(7):665-673
pubmed: 29925983
Nat Med. 2020 Jul;26(7):1070-1076
pubmed: 32514174
Nat Rev Microbiol. 2021 Mar;19(3):141-154
pubmed: 33024307
N Engl J Med. 2018 Mar 08;378(10):931-939
pubmed: 29514034
Science. 2022 Apr 8;376(6589):eabf1970
pubmed: 35389781
Nat Commun. 2022 Jul 13;13(1):4046
pubmed: 35831277
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
Br J Pharmacol. 2011 Oct;164(4):1079-106
pubmed: 21371012
JAMA. 2018 Oct 02;320(13):1360-1372
pubmed: 30285183
Nat Rev Rheumatol. 2021 Jul;17(7):387-404
pubmed: 34113018
Science. 2022 May 13;376(6594):eabl5197
pubmed: 35549406
Nat Commun. 2022 Dec 13;13(1):7729
pubmed: 36513651
Cell. 2019 Sep 5;178(6):1493-1508.e20
pubmed: 31474370
Nature. 2018 Oct;562(7727):367-372
pubmed: 30283141
Maedica (Bucur). 2010 Apr;5(2):132-4
pubmed: 21977137
Med (N Y). 2021 Mar 12;2(3):296-312.e8
pubmed: 33748804
J Immunol. 2014 Jul 15;193(2):849-59
pubmed: 24951817
Science. 2021 Jan 8;371(6525):145-153
pubmed: 33414215
Nature. 1992 Mar 26;356(6367):314-7
pubmed: 1372394
Arthritis Res Ther. 2017 Sep 7;19(1):198
pubmed: 28882159
Front Immunol. 2022 May 13;13:838636
pubmed: 35634297
Sci Immunol. 2022 Apr 15;7(70):eabl9165
pubmed: 35427179
J Allergy Clin Immunol. 2021 Nov;148(5):1281-1292
pubmed: 33932468
Nat Immunol. 2020 Sep;21(9):1094-1106
pubmed: 32747814
Immune Netw. 2016 Aug;16(4):219-32
pubmed: 27574501
Front Immunol. 2021 Feb 02;11:594658
pubmed: 33603736
Nat Rev Immunol. 2022 Dec;22(12):734-750
pubmed: 35508809
Nat Rev Immunol. 2004 Aug;4(8):648-55
pubmed: 15286731