Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
10
06
2022
accepted:
12
01
2023
entrez:
1
3
2023
pubmed:
2
3
2023
medline:
4
3
2023
Statut:
ppublish
Résumé
Modern humans have populated Europe for more than 45,000 years
Identifiants
pubmed: 36859578
doi: 10.1038/s41586-023-05726-0
pii: 10.1038/s41586-023-05726-0
pmc: PMC9977688
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-126Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
Références
Prüfer, K. et al. A genome sequence from a modern human skull over 45,000 years old from Zlatý kůň in Czechia. Nat. Ecol. Evol. 5, 820–825 (2021).
pubmed: 33828249
pmcid: 8175239
doi: 10.1038/s41559-021-01443-x
Hajdinjak, M. et al. Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry. Nature 592, 253–257 (2021).
pubmed: 33828320
pmcid: 8026394
doi: 10.1038/s41586-021-03335-3
Olalde, I. & Posth, C. Latest trends in archaeogenetic research of west Eurasians. Curr. Opin. Genet. Dev. 62, 36–43 (2020).
pubmed: 32610222
doi: 10.1016/j.gde.2020.05.021
Fu, Q. et al. The genetic history of Ice Age Europe. Nature 534, 200–205 (2016).
pubmed: 27135931
pmcid: 4943878
doi: 10.1038/nature17993
Green, R. E. et al. A draft sequence of the Neandertal genome. Science 328, 710–722 (2010).
pubmed: 20448178
pmcid: 5100745
doi: 10.1126/science.1188021
Fu, Q. et al. An early modern human from Romania with a recent Neanderthal ancestor. Nature 524, 216–219 (2015).
pubmed: 26098372
pmcid: 4537386
doi: 10.1038/nature14558
Fu, Q. et al. Genome sequence of a 45,000-year-old modern human from western Siberia. Nature 514, 445–449 (2014).
pubmed: 25341783
pmcid: 4753769
doi: 10.1038/nature13810
Seguin-Orlando, A. et al. Genomic structure in Europeans dating back at least 36,200 years. Science 346, 1113–1118 (2014).
pubmed: 25378462
doi: 10.1126/science.aaa0114
Vallini, L. et al. Genetics and material culture support repeated expansions into Paleolithic Eurasia from a population hub out of Africa. Genome Biol. Evol. 14, evac045 (2022).
pubmed: 35445261
pmcid: 9021735
doi: 10.1093/gbe/evac045
Maier, A. & Zimmermann, A. Populations headed south? The Gravettian from a palaeodemographic point of view. Antiquity 91, 573–588 (2017).
doi: 10.15184/aqy.2017.37
Dolukhanov, P. in Cultural Transformations and Interactions in Eastern Europe (eds Chapman, J. & Dolukhanov, P.) 122–145 (Avebury, 1993).
Gamble, C., Davies, W., Pettitt, P., Hazelwood, L. & Richards, M. The archaeological and genetic foundations of the European population during the Late Glacial: implications for ‘agricultural thinking’. Cambridge Archaeol. J. 15, 193–223 (2005).
doi: 10.1017/S0959774305000107
Wren, C. D. & Burke, A. Habitat suitability and the genetic structure of human populations during the Last Glacial Maximum (LGM) in Western Europe. PLoS ONE 14, e0217996 (2019).
pubmed: 31216315
pmcid: 6583941
doi: 10.1371/journal.pone.0217996
Villalba-Mouco, V. et al. Survival of Late Pleistocene hunter-gatherer ancestry in the Iberian Peninsula. Curr. Biol. 29, 1169–1177.e7 (2019).
pubmed: 30880015
doi: 10.1016/j.cub.2019.02.006
Bortolini, E. et al. Early Alpine occupation backdates westward human migration in Late Glacial Europe. Curr. Biol. 31, 2484–2493.e7 (2021).
pubmed: 33887180
doi: 10.1016/j.cub.2021.03.078
Feldman, M. et al. Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia. Nat. Commun. 10, 1218 (2019).
pubmed: 30890703
pmcid: 6425003
doi: 10.1038/s41467-019-09209-7
Petr, M., Pääbo, S., Kelso, J. & Vernot, B. Limits of long-term selection against Neandertal introgression. Proc. Natl Acad. Sci. USA 116, 1639–1644 (2019).
pubmed: 30647110
pmcid: 6358679
doi: 10.1073/pnas.1814338116
Harris, K. & Nielsen, R. The genetic cost of Neanderthal introgression. Genetics 203, 881–891 (2016).
pubmed: 27038113
pmcid: 4896200
doi: 10.1534/genetics.116.186890
Kozłowski, J. K. The origin of the Gravettian. Quat. Int. 359, 3–18 (2015).
doi: 10.1016/j.quaint.2014.03.025
Goutas, N. in Les Gravettiens (ed. Otte, M.) 105–160 (Errance, 2013).
Klaric, L., Goutas, N., Laccarière, J. & Banks, W. E. in Les Sociétés Gravettiennes du Nord-Ouest Européen: Nouveaux Sites, Nouvelles Données, Nouvelles Lectures (eds Touzé, O., Goutas, N., Salomon, H. & Noiret, P.) 323–266 (Presses Univ. de Liège, 2021).
Mounier, A. et al. Gravettian cranial morphology and human group affinities during the European Upper Palaeolithic. Sci. Rep. 10, 21931 (2020).
pubmed: 33318530
pmcid: 7736346
doi: 10.1038/s41598-020-78841-x
Sikora, M. et al. Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers. Science 358, 659–662 (2017).
pubmed: 28982795
doi: 10.1126/science.aao1807
Posth, C. et al. Pleistocene mitochondrial genomes suggest a single major dispersal of non-Africans and a Late Glacial Population turnover in Europe. Curr. Biol. 26, 827–833 (2016).
pubmed: 26853362
doi: 10.1016/j.cub.2016.01.037
Straus, L. G. The human occupation of southwestern Europe during the Last Glacial Maximum: Solutrean cultural adaptations in France and Iberia. J. Anthropol. Res. 71, 465–492 (2015).
doi: 10.3998/jar.0521004.0071.401
Lécuyer, C., Hillaire-Marcel, C., Burke, A., Julien, M. A. & Hélie, J. F. Temperature and precipitation regime in LGM human refugia of southwestern Europe inferred from δ
doi: 10.1016/j.quascirev.2021.106796
Djindjian, F. Territories and economies of hunter-gatherer groups during the last glacial maximum in Europe. Quat. Int. 412, 37–43 (2016).
doi: 10.1016/j.quaint.2015.06.058
Ruiz-Redondo, A. et al. Mid and Late Upper Palaeolithic in the Adriatic Basin: chronology, transitions and human adaptations to a changing landscape. Quat. Sci. Rev. 276, 107319 (2022).
doi: 10.1016/j.quascirev.2021.107319
Laplace, G. Essai de Typologie Systématique (Annali dell’Università di Ferrara, 1964).
Yu, H. et al. Genomic and dietary discontinuities during the Mesolithic and Neolithic in Sicily. iScience 25, 104244 (2022).
pubmed: 35494246
pmcid: 9051636
doi: 10.1016/j.isci.2022.104244
Palma di Cesnola, A. Le paléolithique supérieur en Italie. Série ‘Préhistoire d’Europe’ 9 (Éditions, 2001).
Peresani, M. et al. Hunter-gatherers across the great Adriatic-Po region during the Last Glacial Maximum: environmental and cultural dynamics. Quat. Int. 581–582, 128–163 (2021).
doi: 10.1016/j.quaint.2020.10.007
Otte, M. Appearance, expansion and dilution of the Magdalenian civilization. Quat. Int. 272–273, 354–361 (2012).
doi: 10.1016/j.quaint.2012.02.056
Maier, A. in The Central European Magdalenian 81–180 https://doi.org/10.1007/978-94-017-7206-8_6 (Springer, 2015).
Kozłowski, S. K., Połtowicz-Bobak, M., Bobak, D. & Terberger, T. New information from Maszycka Cave and the Late Glacial recolonisation of Central Europe. Quat. Int. 272, 288–296 (2012).
doi: 10.1016/j.quaint.2012.02.052
Raghavan, M. et al. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature 505, 87–91 (2014).
pubmed: 24256729
doi: 10.1038/nature12736
Mathieson, I. et al. Genome-wide patterns of selection in 230 ancient Eurasians. Nature 528, 499–503 (2015).
pubmed: 26595274
pmcid: 4918750
doi: 10.1038/nature16152
Mathieson, I. et al. The genomic history of southeastern Europe. Nature 555, 197–203 (2018).
pubmed: 29466330
pmcid: 6091220
doi: 10.1038/nature25778
Mittnik, A. et al. The genetic prehistory of the Baltic Sea region. Nat. Commun. 9, 442 (2018).
pubmed: 29382937
pmcid: 5789860
doi: 10.1038/s41467-018-02825-9
Günther, T. et al. Population genomics of Mesolithic Scandinavia: investigating early postglacial migration routes and high-latitude adaptation. PLoS Biol. 16, e2003703 (2018).
pubmed: 29315301
pmcid: 5760011
doi: 10.1371/journal.pbio.2003703
Charlton, S. et al. Dual ancestries and ecologies of the Late Glacial Palaeolithic in Britain. Nat. Ecol. Evol. 6, 1658–1668 (2022).
pubmed: 36280785
pmcid: 9630104
doi: 10.1038/s41559-022-01883-z
Damgaard, P. et al. The first horse herders and the impact of early Bronze Age steppe expansions into Asia. Science 360, eaar7711 (2018).
doi: 10.1126/science.aar7711
Saag, L. et al. Genetic ancestry changes in Stone to Bronze Age transition in the East European plain. Sci. Adv. 7, eabd6535 (2021).
pubmed: 33523926
pmcid: 7817100
doi: 10.1126/sciadv.abd6535
Wood, R. E. et al. Freshwater radiocarbon reservoir effects at the burial ground of Minino, Northwest Russia. Radiocarbon 55, 163–177 (2013).
doi: 10.2458/azu_js_rc.v55i1.16448
Narasimhan, V. M. et al. The formation of human populations in South and Central Asia. Science 365, eaat7487 (2019).
pubmed: 31488661
pmcid: 6822619
doi: 10.1126/science.aat7487
Gronenborn, D. in The Spread of the Neolithic to Central Europe (RGZM, 2010).
Schmitt, T. Molecular biogeography of Europe: Pleistocene cycles and postglacial trends. Front. Zool. 4, 11 (2007).
pubmed: 17439649
pmcid: 1868914
doi: 10.1186/1742-9994-4-11
Roebroeks, W., Mussi, M., Svoboda, J. & Fennema, K. Hunters of the Golden Age: The Mid Upper Palaeolithic of Eurasia, 30,000-20,000 bp (Univ. of Leiden, 2000).
Kotula, A., Piezonka, H. & Tergerger, T. The Mesolithic cemetery of Groß Fredenwalde (north-eastern Germany) and its cultural affiliations. Liet. Archeol. 46, 65–84 (2020).
doi: 10.33918/25386514-046002
Piezonka, H. et al. The emergence of hunter-gatherer pottery in the Urals and West Siberia: new dating and stable isotope evidence. J. Archaeol. Sci. 116, 105100 (2020).
doi: 10.1016/j.jas.2020.105100
Villalba-Mouco, V. et al. A 23,000-year-old southern-Iberian individual links human groups that lived in Western Europe before and after the Last Glacial Maximum. Nat. Ecol. Evol., https://doi.org/10.1038/s41559-023-01987-0 (2023)
Bronk Ramsey, C. Bayesian analysis of radiocarbon dates. Radiocarbon 51, 337–360 (2009).
doi: 10.1017/S0033822200033865
Reimer, P. J. et al. The IntCal20 Northern Hemisphere radiocarbon age calibration curve (0–55 cal kBP). Radiocarbon 62, 725–757 (2020).
doi: 10.1017/RDC.2020.41
Korlević, P. et al. Reducing microbial and human contamination in DNA extractions from ancient bones and teeth. Biotechniques 59, 87–93 (2015).
pubmed: 26260087
doi: 10.2144/000114320
Rohland, N. & Hofreiter, M. Ancient DNA extraction from bones and teeth. Nat. Protoc. 2, 1756–1762 (2007).
pubmed: 17641642
doi: 10.1038/nprot.2007.247
Dabney, J. et al. Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments. Proc. Natl Acad. Sci. USA 110, 15758–63 (2013).
pubmed: 24019490
pmcid: 3785785
doi: 10.1073/pnas.1314445110
Rohland, N., Glocke, I., Aximu-Petri, A. & Meyer, M. Extraction of highly degraded DNA from ancient bones, teeth and sediments for high-throughput sequencing. Nat. Protoc. 13, 2447–2461 (2018).
pubmed: 30323185
doi: 10.1038/s41596-018-0050-5
Rohland, N., Harney, E., Mallick, S., Nordenfelt, S. & Reich, D. Partial uracil–DNA–glycosylase treatment for screening of ancient DNA. Philos. Trans. R. Soc. B 370, 20130624 (2015).
doi: 10.1098/rstb.2013.0624
Meyer, M. & Kircher, M. Illumina sequencing library preparation for highly multiplexed target capture and sequencing. Cold Spring Harb. Protoc. 2010, pdb.prot5448 (2010).
pubmed: 20516186
doi: 10.1101/pdb.prot5448
Kircher, M., Sawyer, S. & Meyer, M. Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform. Nucleic Acids Res. 40, e3 (2012).
pubmed: 22021376
doi: 10.1093/nar/gkr771
Gansauge, M., Aximu-Petri, A., Nagel, S. & Meyer, M. Manual and automated preparation of single-stranded DNA libraries for the sequencing of DNA from ancient biological remains and other sources of highly degraded DNA. Nat. Protoc. 15, 2279–2300 (2020).
pubmed: 32612278
doi: 10.1038/s41596-020-0338-0
Meyer, M. et al. A high-coverage genome sequence from an archaic Denisovan individual. Science 338, 222–226 (2012).
pubmed: 22936568
pmcid: 3617501
doi: 10.1126/science.1224344
Fu, Q. et al. DNA analysis of an early modern human from Tianyuan Cave, China. Proc. Natl Acad. Sci. USA 110, 2223–2227 (2013).
pubmed: 23341637
pmcid: 3568306
doi: 10.1073/pnas.1221359110
Peltzer, A. et al. EAGER: efficient ancient genome reconstruction. Genome Biol. 17, 60 (2016).
pubmed: 27036623
pmcid: 4815194
doi: 10.1186/s13059-016-0918-z
Schubert, M., Lindgreen, S. & Orlando, L. AdapterRemoval v2: rapid adapter trimming, identification, and read merging. BMC Res. Notes 9, 88 (2016).
pubmed: 26868221
pmcid: 4751634
doi: 10.1186/s13104-016-1900-2
Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows–Wheeler transform. Bioinformatics 25, 1754–1760 (2009).
pubmed: 19451168
pmcid: 2705234
doi: 10.1093/bioinformatics/btp324
Jónsson, H., Ginolhac, A., Schubert, M., Johnson, P. L. F. & Orlando, L. MapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters. Bioinformatics 29, 1682–1684 (2013).
pubmed: 23613487
pmcid: 3694634
doi: 10.1093/bioinformatics/btt193
Skoglund, P. et al. Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. Proc. Natl Acad. Sci. USA 111, 2229–2234 (2014).
pubmed: 24469802
pmcid: 3926038
doi: 10.1073/pnas.1318934111
Renaud, G., Slon, V., Duggan, A. T. & Kelso, J. Schmutzi: estimation of contamination and endogenous mitochondrial consensus calling for ancient DNA. Genome Biol. 16, 224 (2015).
pubmed: 26458810
pmcid: 4601135
doi: 10.1186/s13059-015-0776-0
Korneliussen, T. S., Albrechtsen, A. & Nielsen, R. ANGSD: analysis of next generation sequencing data. BMC Bioinformatics 15, 356 (2014).
pubmed: 25420514
pmcid: 4248462
doi: 10.1186/s12859-014-0356-4
Huang, Y. & Ringbauer, H. hapCon: estimating contamination of ancient genomes by copying from reference haplotypes. Bioinformatics 38, 3768–3777 (2022).
pubmed: 35695771
pmcid: 9344841
doi: 10.1093/bioinformatics/btac390
Nakatsuka, N. et al. ContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium. Genome Biol. 21, 199 (2020).
pubmed: 32778142
pmcid: 7418405
doi: 10.1186/s13059-020-02111-2
Li, H. et al. The sequence alignment/map format and SAMtools. Bioinformatics 25, 2078–2079 (2009).
pubmed: 19505943
pmcid: 2723002
doi: 10.1093/bioinformatics/btp352
Catalano, G. et al. Late Upper Palaeolithic hunter-gatherers in the Central Mediterranean: new archaeological and genetic data from the Late Epigravettian burial Oriente C (Favignana, Sicily). Quat. Int. 537, 24–32 (2020).
doi: 10.1016/j.quaint.2020.01.025
Jensen, T. Z. T. et al. A 5700 year-old human genome and oral microbiome from chewed birch pitch. Nat. Commun. 10, 5520–10 (2019).
pubmed: 31848342
pmcid: 6917805
doi: 10.1038/s41467-019-13549-9
Key, F. M. et al. Emergence of human-adapted Salmonella enterica is linked to the Neolithization process. Nat. Ecol. Evol. 4, 324–333 (2020).
pubmed: 32094538
pmcid: 7186082
doi: 10.1038/s41559-020-1106-9
Rivollat, M. et al. Ancient genome-wide DNA from France highlights the complexity of interactions between Mesolithic hunter-gatherers and Neolithic farmers. Sci. Adv. 6, eaaz5344 (2020).
pubmed: 32523989
pmcid: 7259947
doi: 10.1126/sciadv.aaz5344
Svensson, E. et al. Genome of Peştera Muierii skull shows high diversity and low mutational load in pre-glacial Europe. Curr. Biol. 31, 2973–2983.e9 (2021).
pubmed: 34010592
doi: 10.1016/j.cub.2021.04.045
Antonio, M. L. et al. Ancient Rome: A genetic crossroads of Europe and the Mediterranean. Science 366, 708–714 (2019).
pubmed: 31699931
pmcid: 7093155
doi: 10.1126/science.aay6826
Brace, S. et al. Ancient genomes indicate population replacement in Early Neolithic Britain. Nat. Ecol. Evol. 3, 765–771 (2019).
pubmed: 30988490
pmcid: 6520225
doi: 10.1038/s41559-019-0871-9
Brunel, S. et al. Ancient genomes from present-day France unveil 7,000 years of its demographic history. Proc. Natl Acad. Sci. USA 117, 12791–12798 (2020).
pubmed: 32457149
pmcid: 7293694
doi: 10.1073/pnas.1918034117
Cassidy, L. M. et al. A dynastic elite in monumental Neolithic society. Nature 582, 384–388 (2020).
pubmed: 32555485
pmcid: 7116870
doi: 10.1038/s41586-020-2378-6
González-Fortes, G. et al. Paleogenomic evidence for multi-generational mixing between Neolithic farmers and Mesolithic hunter-gatherers in the Lower Danube Basin. Curr. Biol. 27, 1801–1810.e10 (2017).
pubmed: 28552360
pmcid: 5483232
doi: 10.1016/j.cub.2017.05.023
Jones, E. R. et al. Upper Palaeolithic genomes reveal deep roots of modern Eurasians. Nat. Commun. 6, 8912 (2015).
pubmed: 26567969
doi: 10.1038/ncomms9912
Jones, E. R. et al. The Neolithic transition in the Baltic was not driven by admixture with early European farmers. Curr. Biol. 27, 576–582 (2017).
pubmed: 28162894
pmcid: 5321670
doi: 10.1016/j.cub.2016.12.060
Lazaridis, I. et al. Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature 513, 409–413 (2014).
pubmed: 25230663
pmcid: 4170574
doi: 10.1038/nature13673
Lazaridis, I. et al. Genomic insights into the origin of farming in the ancient Near East. Nature 536, 419–424 (2016).
pubmed: 27459054
pmcid: 5003663
doi: 10.1038/nature19310
Lipson, M. et al. Parallel palaeogenomic transects reveal complex genetic history of early European farmers. Nature 551, 368–372 (2017).
pubmed: 29144465
pmcid: 5973800
doi: 10.1038/nature24476
van de Loosdrecht, M. et al. Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations. Science 360, 548–552 (2018).
pubmed: 29545507
doi: 10.1126/science.aar8380
Olalde, I. et al. The genomic history of the Iberian Peninsula over the past 8,000 years. Science 363, 1230–1234 (2019).
pubmed: 30872528
pmcid: 6436108
doi: 10.1126/science.aav4040
Saag, L. et al. Extensive farming in Estonia started through a sex-biased migration from the steppe. Curr. Biol. 27, 2185–2193.e6 (2017).
pubmed: 28712569
doi: 10.1016/j.cub.2017.06.022
Sikora, M. et al. The population history of northeastern Siberia since the Pleistocene. Nature 570, 182–188 (2019).
pubmed: 31168093
doi: 10.1038/s41586-019-1279-z
Skoglund, P. et al. Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. Science 344, 747–750 (2014).
pubmed: 24762536
doi: 10.1126/science.1253448
Yang, M. A. et al. 40,000-year-old individual from Asia provides insight into early population structure in Eurasia. Curr. Biol. 27, 3202–3208.e9 (2017).
pubmed: 29033327
pmcid: 6592271
doi: 10.1016/j.cub.2017.09.030
Weissensteiner, H. et al. HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing. Nucleic Acids Res. 44, W58–W63 (2016).
pubmed: 27084951
pmcid: 4987869
doi: 10.1093/nar/gkw233
Edgar, R. C. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32, 1792–1797 (2004).
pubmed: 15034147
pmcid: 390337
doi: 10.1093/nar/gkh340
Kumar, S., Stecher, G., Li, M., Knyaz, C. & Tamura, K. MEGA X: molecular evolutionary genetics analysis across computing platforms. Mol. Biol. Evol. 35, 1547–1549 (2018).
pubmed: 29722887
pmcid: 5967553
doi: 10.1093/molbev/msy096
Rohrlach, A. B. et al. Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidence for a two-path Neolithic expansion to Western Europe. Sci. Rep. 11, 15005 (2021).
pubmed: 34294811
pmcid: 8298398
doi: 10.1038/s41598-021-94491-z
Martiniano, R., De Sanctis, B., Hallast, P. & Durbin, R. Placing ancient DNA sequences into reference phylogenies. Mol. Biol. Evol. 39, msac017 (2022).
pubmed: 35084493
pmcid: 8857924
doi: 10.1093/molbev/msac017
Karmin, M. et al. A recent bottleneck of Y chromosome diversity coincides with a global change in culture. Genome Res. 25, 459–466 (2015).
pubmed: 25770088
pmcid: 4381518
doi: 10.1101/gr.186684.114
Ringbauer, H., Novembre, J. & Steinrücken, M. Parental relatedness through time revealed by runs of homozygosity in ancient DNA. Nat. Commun. 12, 5425 (2021).
pubmed: 34521843
pmcid: 8440622
doi: 10.1038/s41467-021-25289-w
Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. PLoS Genet. 2, e190 (2006).
pubmed: 17194218
pmcid: 1713260
doi: 10.1371/journal.pgen.0020190
Patterson, N. et al. Ancient admixture in human history. Genetics 192, 1065–1093 (2012).
pubmed: 22960212
pmcid: 3522152
doi: 10.1534/genetics.112.145037
Paradis, E., Claude, J. & Strimmer, K. APE: analyses of phylogenetics and evolution in R language. Bioinformatics 20, 289–290 (2004).
pubmed: 14734327
doi: 10.1093/bioinformatics/btg412
Chintalapati, M., Patterson, N. & Moorjani, P. The spatiotemporal patterns of major human admixture events during the European Holocene. eLife 11, e77625 (2022).
pubmed: 35635751
pmcid: 9293011
doi: 10.7554/eLife.77625