Combined Treatment with a WNT Inhibitor and the NSAID Sulindac Reduces Colon Adenoma Burden in Mice with Truncated APC.
Journal
Cancer research communications
ISSN: 2767-9764
Titre abrégé: Cancer Res Commun
Pays: United States
ID NLM: 9918281580506676
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
27
10
2021
revised:
20
12
2021
accepted:
18
01
2022
entrez:
2
3
2023
pubmed:
3
3
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Adenomatous polyposis coli (APC) truncations occur in many colorectal cancers and are often associated with immune infiltration. The aim of this study was to determine whether a combination of Wnt inhibition with anti-inflammatory (sulindac) and/or proapototic (ABT263) drugs can reduce colon adenomas. Colorectal cancer is one of the most common cancers worldwide with limited therapeutic options. APC and other Wnt signaling mutations occur in the majority of colorectal cancers but there are currently no Wnt inhibitors in the clinic. The combination of Wnt pathway inhibition with sulindac provides an opportunity for killing
Identifiants
pubmed: 36860494
doi: 10.1158/2767-9764.CRC-21-0105
pii: CRC-21-0105-ET
pmc: PMC9973414
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
navitoclax
XKJ5VVK2WD
Protein Serine-Threonine Kinases
EC 2.7.11.1
Sulindac
184SNS8VUH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
66-77Informations de copyright
© 2022 The Authors; Published by the American Association for Cancer Research.
Déclaration de conflit d'intérêts
M.C. Faux reports grants from National Health and Medical Research Council of Australia during the conduct of the study. No other disclosures were reported.
Références
Cell. 1996 Oct 18;87(2):159-70
pubmed: 8861899
Cell Death Dis. 2020 Sep 10;11(9):735
pubmed: 32913182
Br J Cancer. 2004 Jan 12;90(1):224-9
pubmed: 14710233
Blood. 2004 Feb 1;103(3):1050-8
pubmed: 14525778
Nat Rev Genet. 2001 Oct;2(10):769-79
pubmed: 11584293
Dis Colon Rectum. 2020 Feb;63(2):160-171
pubmed: 31842159
Am J Physiol Gastrointest Liver Physiol. 2017 Oct 1;313(4):G285-G299
pubmed: 28684459
Methods Mol Biol. 2009;530:325-42
pubmed: 19266340
Clin Cancer Res. 2019 May 15;25(10):3074-3083
pubmed: 30635339
Blood. 2012 Jun 14;119(24):5807-16
pubmed: 22538851
Cancer Cell. 2013 Aug 12;24(2):257-71
pubmed: 23948300
N Engl J Med. 1993 May 6;328(18):1313-6
pubmed: 8385741
Nat Commun. 2016 Mar 09;7:10916
pubmed: 26956214
N Engl J Med. 2002 Apr 4;346(14):1054-9
pubmed: 11932472
Nature. 2016 Oct 27;538(7626):477-482
pubmed: 27760111
Carcinogenesis. 1996 Aug;17(8):1757-60
pubmed: 8761438
Science. 1992 May 1;256(5057):668-70
pubmed: 1350108
Cancer Med. 2022 Jul;11(13):2612-2626
pubmed: 35301819
Nature. 2009 Jan 29;457(7229):608-11
pubmed: 19092804
Int J Cancer. 2006 Jan 1;118(1):25-34
pubmed: 16049979
Science. 1998 May 15;280(5366):1036-7
pubmed: 9616081
Cell. 2012 Mar 30;149(1):146-58
pubmed: 22464327
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6991-5
pubmed: 7624356
PLoS Genet. 2010 Jan 15;6(1):e1000816
pubmed: 20084116
Curr Protoc Stem Cell Biol. 2010 May;Chapter 5:Unit5A.4
pubmed: 20443207
Science. 1990 Jan 19;247(4940):322-4
pubmed: 2296722
J Clin Invest. 2014 Mar;124(3):1283-95
pubmed: 24487592
Clin Cancer Res. 2008 Jun 1;14(11):3268-77
pubmed: 18519752
PLoS One. 2008;3(12):e3951
pubmed: 19079611
Cell. 2012 Jun 8;149(6):1192-205
pubmed: 22682243
Am J Med. 2020 Jul;133(7):e389-e390
pubmed: 32600553
Science. 1997 Oct 3;278(5335):120-3
pubmed: 9311916
PLoS One. 2014 Jul 08;9(7):e101969
pubmed: 25003333
Nature. 2007 Oct 25;449(7165):1003-7
pubmed: 17934449
Am J Med Sci. 2018 Mar;355(3):274-280
pubmed: 29549930
Nat Genet. 1999 Jan;21(1):70-1
pubmed: 9916792
Cell Death Differ. 2021 Dec;28(12):3282-3296
pubmed: 34117376
Gut. 1996 Apr;38(4):578-81
pubmed: 8707091
Gut. 2018 Jul;67(7):1290-1298
pubmed: 29122850
Carcinogenesis. 2003 Feb;24(2):263-7
pubmed: 12584176
Nat Rev Cancer. 2018 Mar;18(3):139-147
pubmed: 29326431
Nat Chem Biol. 2010 Nov;6(11):829-36
pubmed: 20890287
JNCI Cancer Spectr. 2020 Oct 07;5(1):
pubmed: 33442661
Curr Drug Targets. 2019;20(3):302-315
pubmed: 30073924
Cell Death Dis. 2020 Oct 17;11(10):875
pubmed: 33070156
Science. 1991 Aug 9;253(5020):661-5
pubmed: 1651562
Gastroenterology. 2001 Dec;121(6):1407-16
pubmed: 11729120
Lancet. 1992 Sep 12;340(8820):626-30
pubmed: 1355210