Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals

Humans Mice Animals Female Tumor Suppressor Protein p53 / genetics Mutation / genetics Breast Neoplasms / genetics Aneuploidy Carcinoma, Squamous Cell

Journal

Cancer research communications
ISSN: 2767-9764
Titre abrégé: Cancer Res Commun
Pays: United States
ID NLM: 9918281580506676

Informations de publication

Date de publication:
02 2023
Historique:
received: 12 03 2022
revised: 08 10 2022
accepted: 20 01 2023
entrez: 2 3 2023
pubmed: 3 3 2023
medline: 3 3 2023
Statut: epublish

Résumé

The hallmark signatures based on gene expression capture core cancer processes. Through a pan-cancer analysis, we describe the overview of hallmark signatures across tumor types/subtypes and reveal significant relationships between these signatures and genetic alterations. Our data demonstrate that

Identifiants

DOI: 10.1158/2767-9764.CRC-22-0073 PMID: 36860655 PMC: PMC9973382
pubmed: 36860655
doi: 10.1158/2767-9764.CRC-22-0073
pii: CRC-22-0073
pmc: PMC9973382
doi:

Substances chimiques

Tumor Suppressor Protein p53 0
TP53 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

281-296

Subventions

Organisme : NCI NIH HHS
ID : P20 CA233307
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA148761
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD013452
Pays : United States

Informations de copyright

© 2023 The Authors; Published by the American Association for Cancer Research.

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Auteurs

Marni B McClure (MB)

Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
ORCID: 0000-0002-0807-4368

Yasunori Kogure (Y)

Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.
ORCID: 0000-0003-1158-5131

Naser Ansari-Pour (N)

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
ORCID: 0000-0003-0908-0484

Yuki Saito (Y)

Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.
Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.
ORCID: 0000-0003-2686-9604

Hann-Hsiang Chao (HH)

Department of Radiation Oncology, Richmond VA Medical Center, Richmond, Virginia.
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia.
ORCID: 0000-0003-1096-0884

Jonathan Shepherd (J)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
ORCID: 0000-0001-6322-6347

Mariko Tabata (M)

Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.
Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
ORCID: 0000-0002-8013-7327

Olufunmilayo I Olopade (OI)

Center for Clinical Cancer Genetics & Global Health, University of Chicago School of Medicine, The University of Chicago, Chicago, Illinois.
ORCID: 0000-0002-9936-1599

David C Wedge (DC)

Manchester Cancer Research Centre, University of Manchester, Manchester, United Kingdom.
ORCID: 0000-0002-7572-3196

Katherine A Hoadley (KA)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
ORCID: 0000-0002-1216-477X

Charles M Perou (CM)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
ORCID: 0000-0001-9827-2247

Keisuke Kataoka (K)

Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.
Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
ORCID: 0000-0002-8263-9902

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Landscape of Genetic Alterations Underlying...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Landscape of Genetic Alterations Underlying...
questionsmedicales.fr › Eucaryotes › Animaux › Landscape of Genetic Alterations Underlying...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Landscape of Genetic Alterations Underlying...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Landscape of Genetic Alterations Underlying...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Landscape of Genetic Alterations Underlying...
questionsmedicales.fr › Phénomènes génétiques › Ploïdies › Aneuploïdie › Landscape of Genetic Alterations Underlying...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Landscape of Genetic Alterations Underlying...