Glycine receptor autoantibody binding to the extracellular domain is independent from receptor glycosylation.
adsorption
autoantibodies
extracellular domain
glycine receptor
glycosylation
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2023
2023
Historique:
received:
03
11
2022
accepted:
19
01
2023
entrez:
2
3
2023
pubmed:
3
3
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Glycine receptor (GlyR) autoantibodies are associated with stiff-person syndrome and the life-threatening progressive encephalomyelitis with rigidity and myoclonus in children and adults. Patient histories show variability in symptoms and responses to therapeutic treatments. A better understanding of the autoantibody pathology is required to develop improved therapeutic strategies. So far, the underlying molecular pathomechanisms include enhanced receptor internalization and direct receptor blocking altering GlyR function. A common epitope of autoantibodies against the GlyRα1 has been previously defined to residues
Identifiants
pubmed: 36860666
doi: 10.3389/fnmol.2023.1089101
pmc: PMC9969106
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1089101Informations de copyright
Copyright © 2023 Rauschenberger, Piro, Kasaragod, Hörlin, Eckes, Kluck, Schindelin, Meinck, Wickel, Geis, Tüzün, Doppler, Sommer and Villmann.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neuron. 2021 Sep 1;109(17):2707-2716.e6
pubmed: 34473954
Epilepsia. 2014 Mar;55(3):414-22
pubmed: 24502404
Ann Neurol. 2020 Sep;88(3):544-561
pubmed: 32588476
Mol Reprod Dev. 2015 Jul-Aug;82(7-8):518-29
pubmed: 26153368
FEBS Lett. 1994 Aug 15;350(1):71-6
pubmed: 8062927
Neurol Neuroimmunol Neuroinflamm. 2015 Dec 10;3(1):e186
pubmed: 26767190
Nature. 2015 Oct 8;526(7572):224-9
pubmed: 26344198
J Biol Chem. 2014 Mar 14;289(11):7907-18
pubmed: 24497634
Nat Struct Mol Biol. 2022 Jun;29(6):507-518
pubmed: 35637422
Brain. 2019 Nov 1;142(11):3398-3410
pubmed: 31591639
Ther Apher. 2001 Jun;5(3):186-92
pubmed: 11467755
Front Mol Neurosci. 2018 Aug 21;11:291
pubmed: 30186111
Ann N Y Acad Sci. 2012 Dec;1274:92-8
pubmed: 23252902
Physiol Rev. 2004 Oct;84(4):1051-95
pubmed: 15383648
Neurol Neuroimmunol Neuroinflamm. 2015 Jul 02;2(4):e127
pubmed: 26185774
Brain. 2014 Aug;137(Pt 8):2178-92
pubmed: 24951641
EMBO J. 1999 Sep 1;18(17):4711-21
pubmed: 10469650
Glycobiology. 2011 Sep;21(9):1147-60
pubmed: 21303814
Methods Mol Biol. 2023;2578:17-25
pubmed: 36152277
Front Mol Neurosci. 2019 Aug 07;12:191
pubmed: 31440140
J Neurosci. 2015 Jan 7;35(1):422-37
pubmed: 25568133
JAMA Neurol. 2016 Jun 1;73(6):714-20
pubmed: 27065452
Physiol Rev. 2017 Apr;97(2):839-887
pubmed: 28298428
Proc Staff Meet Mayo Clin. 1963 May 22;38:203-12
pubmed: 13955116
J Biol Chem. 2004 Jan 16;279(3):1627-36
pubmed: 14593111
Sci Rep. 2017 Sep 7;7(1):10899
pubmed: 28883437
Ther Apher. 2001 Feb;5(1):64-7
pubmed: 11258614
Transfusion. 1999 Jul;39(7):671-3
pubmed: 10413272
J Exp Med. 2021 Nov 1;218(11):
pubmed: 34546336
Nat Genet. 1994 Jun;7(2):131-5
pubmed: 7920629
Transfusion. 2014 Jul;54(7):1851-6
pubmed: 24527774
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Mol Psychiatry. 2017 Dec;22(12):1776-1784
pubmed: 27502473
Nature. 2021 Nov;599(7885):513-517
pubmed: 34555840
Nature. 2015 Oct 8;526(7572):277-80
pubmed: 26416729
JAMA Neurol. 2013 Apr;70(4):498-501
pubmed: 23380884
Neurology. 2008 Oct 14;71(16):1291-2
pubmed: 18852446
J Neurosci. 2012 Aug 8;32(32):11082-94
pubmed: 22875940
Nat Commun. 2022 Feb 17;13(1):923
pubmed: 35177668
Front Mol Neurosci. 2015 Dec 22;8:79
pubmed: 26733802
Cell. 2022 Jul 7;185(14):2469-2477.e13
pubmed: 35803245
JAMA Neurol. 2013 Jan;70(1):44-50
pubmed: 23090334
N Engl J Med. 1989 Jun 1;320(22):1499
pubmed: 2716805
Transfus Apher Sci. 2019 Jun;58(3):310-312
pubmed: 30952585
EMBO J. 1993 Oct;12(10):3729-37
pubmed: 8404844