PET Imaging of Hepatocellular Carcinoma Using ZD2-(
EDB fibronectin
peptide ligand
positron emission tomography
woodchuck model
Journal
Journal of hepatocellular carcinoma
ISSN: 2253-5969
Titre abrégé: J Hepatocell Carcinoma
Pays: New Zealand
ID NLM: 101674775
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
10
2022
accepted:
14
02
2023
entrez:
2
3
2023
pubmed:
3
3
2023
medline:
3
3
2023
Statut:
epublish
Résumé
We tested a recently developed short peptide radioligand for PET imaging of hepatocellular carcinoma (HCC) by targeting an oncoprotein, extra-domain B fibronectin (EDB-FN) in the tumor microenvironment. The radioligand consists of a small linear peptide ZD2 with For ZD2 avid liver tumors, the radioligand accumulation plateaued a few minutes after injection, while the liver background uptake stabilized 20 min post-injection. The status of EDB-FN in woodchuck HCC was confirmed by histology and validated by PCR and western blocking. We have showed the viability of using the ZD2 short peptide radioligand targeting EDB-FN in liver tumor tissue for PET imaging of HCC, which can potentially impact the clinical care for HCC patients.
Identifiants
pubmed: 36860804
doi: 10.2147/JHC.S390939
pii: 390939
pmc: PMC9968869
doi:
Types de publication
Journal Article
Langues
eng
Pagination
291-301Informations de copyright
© 2023 Sergeeva et al.
Déclaration de conflit d'intérêts
Dr Songqi Gao reports a patent WO2020150617A8 licensed to CWRU. Dr Zheng-Rong Lu reports a patent US Patent App. 17/424,104 pending to Molecular Theranostics, LLC. The authors report no other conflicts of interest in this work.
Références
Mol Imaging Biol. 2007 May-Jun;9(3):135-43
pubmed: 17308952
Clin Cancer Res. 2003 Feb;9(2):571-9
pubmed: 12576420
Cancer Res. 2015 Jun 1;75(11):2316-2325
pubmed: 25858145
Br J Radiol. 2012 Sep;85(1017):e573-83
pubmed: 22919011
Genome Biol. 2014;15(12):550
pubmed: 25516281
Mol Pharm. 2010 Dec 6;7(6):2077-92
pubmed: 20698576
J Cancer Res Clin Oncol. 2008 Oct;134(10):1059-65
pubmed: 18386055
Mol Imaging Biol. 2014 Feb;16(1):44-52
pubmed: 23921714
Comp Biochem Physiol C Toxicol Pharmacol. 2006 Jun;143(2):225-31
pubmed: 16581304
J Comput Chem. 2010 Jan 30;31(2):455-61
pubmed: 19499576
J Nucl Med. 2019 Mar;60(3):386-392
pubmed: 30072500
Hepatology. 1989 Mar;9(3):461-70
pubmed: 2465987
Q J Nucl Med Mol Imaging. 2009 Apr;53(2):144-56
pubmed: 19039303
Clin Cancer Res. 2008 Aug 1;14(15):4951-60
pubmed: 18676770
J Submicrosc Cytol Pathol. 1993 Apr;25(2):285-95
pubmed: 7686813
J Pathol. 1999 Jun;188(2):163-7
pubmed: 10398159
Oral Oncol. 2005 Jan;41(1):82-8
pubmed: 15598590
J Cell Biol. 2017 Nov 6;216(11):3799-3816
pubmed: 29021221
Cancer Detect Prev. 1989;14(2):227-9
pubmed: 2695243
Cancer Res. 1990 Mar 1;50(5):1608-12
pubmed: 2406016
ACS Omega. 2019 Jan 31;4(1):1185-1190
pubmed: 30729224
Mol Imaging Biol. 2011 Feb;13(1):140-51
pubmed: 20401538
Hepatogastroenterology. 2003 Nov-Dec;50(54):2154-6
pubmed: 14696485
Sci Rep. 2012;2:539
pubmed: 22844580
Hepatology. 2012 Sep;56(3):820-30
pubmed: 22431061
J Hepatol. 2017 Feb;66(2):355-362
pubmed: 27693539
Bioconjug Chem. 2017 Apr 19;28(4):1031-1040
pubmed: 28201871
J Nucl Med. 2009 May;50 Suppl 1:122S-50S
pubmed: 19403881
Br J Cancer. 2005 Sep 5;93(5):565-70
pubmed: 16091757
J Nucl Med. 2011 Jan;52(1):98-106
pubmed: 21149484
Cancer Res. 2000 Jan 1;60(1):164-9
pubmed: 10646869
HPB Surg. 2011;2011:789323
pubmed: 21941408
Front Oncol. 2019 Dec 03;9:1351
pubmed: 31850230
Eur J Nucl Med Mol Imaging. 2011 Jul;38(7):1248-56
pubmed: 21344223
Cancer Res. 2010 Jul 1;70(13):5238-48
pubmed: 20516121
Jpn J Cancer Res. 1999 Mar;90(3):320-5
pubmed: 10359047
Cancer Microenviron. 2014 Aug;7(1-2):33-9
pubmed: 24214412
Gastroenterology. 2004 Nov;127(5 Suppl 1):S283-93
pubmed: 15508096
J Biochem Biophys Methods. 2007 Jun 10;70(4):649-55
pubmed: 17399795
Am J Nucl Med Mol Imaging. 2019 Oct 15;9(5):216-229
pubmed: 31772820
Int J Cancer. 1994 Oct 1;59(1):11-6
pubmed: 7927891
J Cell Biol. 2017 Nov 6;216(11):3509-3520
pubmed: 28931556
Int J Cancer. 2006 Mar 15;118(6):1331-9
pubmed: 16381025
Cell Differ Dev. 1990 Dec 2;32(3):409-16
pubmed: 1711920
Cells. 2020 Aug 03;9(8):
pubmed: 32756405
J Nucl Med. 2019 Jun;60(6):801-805
pubmed: 30954939
Theranostics. 2020 Sep 8;10(24):11127-11143
pubmed: 33042274
Mol Imaging Biol. 2014 Aug;16(4):459-68
pubmed: 24488484
J Nucl Med. 2006 Oct;47(10):1707-16
pubmed: 17015908
Hepatology. 2005 Nov;42(5):1208-36
pubmed: 16250051
Blood. 2009 Mar 5;113(10):2265-74
pubmed: 19131554
Bioconjug Chem. 2015 May 20;26(5):830-8
pubmed: 25848940
Curr Cancer Drug Targets. 2014;14(4):407-17
pubmed: 24575976