Free-breathing, Contrast Agent-free Whole-Heart MTC-BOOST Imaging: Single-Center Validation Study in Adult Congenital Heart Disease.

Cardiac MR Angiography

Journal

Radiology. Cardiothoracic imaging
ISSN: 2638-6135
Titre abrégé: Radiol Cardiothorac Imaging
Pays: United States
ID NLM: 101748663

Informations de publication

Date de publication:
Feb 2023
Historique:
received: 07 07 2022
revised: 07 12 2022
accepted: 13 12 2022
entrez: 2 3 2023
pubmed: 3 3 2023
medline: 3 3 2023
Statut: epublish

Résumé

To assess the clinical performance of the three-dimensional, free-breathing, Magnetization Transfer Contrast Bright-and-black blOOd phase-SensiTive (MTC-BOOST) sequence in adult congenital heart disease (ACHD). In this prospective study, participants with ACHD undergoing cardiac MRI between July 2020 and March 2021 were scanned with the clinical T2-prepared balanced steady-state free precession sequence and proposed MTC-BOOST sequence. Four cardiologists scored their diagnostic confidence on a four-point Likert scale for sequential segmental analysis on images acquired with each sequence. Scan times and diagnostic confidence were compared using the Mann-Whitney test. Coaxial vascular dimensions at three anatomic landmarks were measured, and agreement between the research sequence and the corresponding clinical sequence was assessed with Bland-Altman analysis. The study included 120 participants (mean age, 33 years ± 13 [SD]; 65 men). The mean acquisition time of the MTC-BOOST sequence was significantly lower compared with that of the conventional clinical sequence (9 minutes ± 2 vs 14 minutes ± 5; The MTC-BOOST sequence provided efficient, high-quality, and contrast agent-free three-dimensional whole-heart imaging in ACHD, with shorter, more predictable acquisition time and improved diagnostic confidence compared with the reference standard clinical sequence.

Identifiants

DOI: 10.1148/ryct.220146 PMID: 36860831 PMC: PMC9969217
pubmed: 36860831
doi: 10.1148/ryct.220146
pmc: PMC9969217
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e220146

Subventions

Organisme : British Heart Foundation
ID : PG/18/59/33955
Pays : United Kingdom

Informations de copyright

© 2023 by the Radiological Society of North America, Inc.

Déclaration de conflit d'intérêts

Disclosures of conflicts of interest: A. Fotaki No relevant relationships. K.P. No relevant relationships. R.H. No relevant relationships. A.S. No relevant relationships. H.A. No relevant relationships. J.F. No relevant relationships. R.N. Employment contract with Siemens Healthcare; patent related to the technique used in the study (patent no. 20190064299); shareholder in Siemens Healthineers. K.P.K. Employee of Siemens Healthcare. A. Frigiola Provided study material, supervision, data analysis, and proofreading for this study; participation in regular governance meetings. R.M.B. Patent related to the technique used in the study (patent no. 20190064299). C.P. Patent related to the technique used in the study (patent no. 20190064299).

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Auteurs

Anastasia Fotaki (A)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).
ORCID: 0000-0002-0353-5778

Kuberan Pushparajah (K)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).

Reza Hajhosseiny (R)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).
ORCID: 0000-0002-8116-460X

Alina Schneider (A)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).
ORCID: 0000-0003-1749-5110

Harith Alam (H)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).

Joana Ferreira (J)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).

Radhouene Neji (R)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).
ORCID: 0000-0002-6543-4390

Karl P Kunze (KP)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).
ORCID: 0000-0001-6403-2712

Alessandra Frigiola (A)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).

René M Botnar (RM)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).
ORCID: 0000-0003-2811-2509

Claudia Prieto (C)

Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).
ORCID: 0000-0003-4602-2523

Classifications MeSH