Discovery of increased number or interval growth of brain metastases on same-day GammaKnife™ planning MRI: Predicting factors and patient outcomes.

GammaKnife SRS brain metastases

Journal

Journal of radiosurgery and SBRT
ISSN: 2156-4647
Titre abrégé: J Radiosurg SBRT
Pays: United States
ID NLM: 101565296

Informations de publication

Date de publication:
2022
Historique:
received: 08 04 2022
accepted: 15 07 2022
entrez: 2 3 2023
pubmed: 1 1 2022
medline: 1 1 2022
Statut: ppublish

Résumé

To determine factors associated with increased risk of finding new and/or enlarged brain metastases (BM) on GammaKnife™ (GK) MRI and their impact on patient outcomes. 43.9% of patients showed BM growth, 32.9% had additional brain metastases (aBM), and 18.1 % had both. Initial brain metastasis velocity (iBMV) was associated with finding aBM. Time between diagnostic MRI (dMRI) and GK MRI was associated with interval growth and each day increased this risk by 2%. Prior brain metastasectomy and greater time between either dMRI or latest extracranial RT and GK MRI predicted both aBM and BM growth. aBM and/or BM growth led to management change in 1.8% of cases and were not associated with OS or incidence of distant intracranial failure. Number of metastases seen on dMRI and iBMV predicted both aBM and/or BM growth, however, these factors did not significantly affect survival or incidence of distant intracranial failure.

Identifiants

pubmed: 36861002
pii: RSBRT-8-189
pmc: PMC9970740

Types de publication

Journal Article

Langues

eng

Pagination

189-199

Informations de copyright

© 2022 Old City Publishing, Inc.

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Auteurs

Todd R Mereniuk (TR)

Department of Radiation Oncology, Indiana School of Medicine, Indianapolis, IN 46202, USA.

Heather N Burney (HN)

Department of Biostatistics, Indiana School of Medicine, Indianapolis, IN 46202, USA.

Tim Lautenschlaeger (T)

Department of Radiation Oncology, Indiana School of Medicine, Indianapolis, IN 46202, USA.

Gordon A Watson (GA)

Department of Radiation Oncology, Indiana School of Medicine, Indianapolis, IN 46202, USA.

Ryan M Rhome (RM)

Department of Radiation Oncology, Indiana School of Medicine, Indianapolis, IN 46202, USA.

Classifications MeSH