A relatively high proportion of dogs with small apocrine gland anal sac adenocarcinoma (AGASACA) primary tumours present with locoregional lymph node metastasis.
adenocarcinoma
anal sac
lymph node metastasis
Journal
Veterinary and comparative oncology
ISSN: 1476-5829
Titre abrégé: Vet Comp Oncol
Pays: England
ID NLM: 101185242
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
revised:
09
02
2023
received:
20
12
2022
accepted:
24
02
2023
medline:
18
5
2023
pubmed:
3
3
2023
entrez:
2
3
2023
Statut:
ppublish
Résumé
Apocrine gland anal sac adenocarcinoma (AGASACA) is a highly relevant disease in dogs, with a high rate of lymph node (LN) metastasis during the course of disease. A recent study showed that risk for death and disease progression was significantly associated with primary tumour size less than 2 and 1.3 cm, respectively. The objective of this study was to report the proportion of dogs that have primary tumours less than 2 cm in diameter, that are diagnosed with LN metastasis at presentation. This was a single site retrospective study of dogs that underwent treatment for AGASACA. Dogs were included if physical examination primary tumour measurements were available, abdominal staging was performed, and confirmation of abnormal lymph nodes by cytology or histology was done. Over a 5-year period, 116 dogs were included for review with 53 (46%) having metastatic LN at presentation. The metastatic rate for dogs with primary tumours <2 cm was 20% (9 of 46 dogs) compared to 63% (44 of 70 dogs) in dogs with primary tumours ≥2 cm. The association between tumour size group (<2 vs. ≥2 cm) and the presence of metastasis at presentation was significant (P < .0001) with an OR of 7.0 (95% CI: 2.9-15.7). Primary tumour size was significantly associated with LN metastasis at presentation but the proportion of dogs that presented with LN metastasis in the <2 cm group was relatively high. This data suggests that dogs with small tumours may still have aggressive tumour biology.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
327-331Informations de copyright
© 2023 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd.
Références
Berrocal A, Vos JH, van den Ingh TS, Molenbeek RF, van Sluijs FJ. Canine perineal tumours. Zentralbl Veterinarmed A. 1989;36(10):739-749.
Williams LE, Gliatto JM, Dodge RK, et al. Carcinoma of the apocrine glands of the anal sac in dogs: 113 cases (1985-1995). J Am Vet Med Assoc. 2003;223(6):825-831.
Wouda RM, Borrego J, Keuler NS, Stein T. Evaluation of adjuvant carboplatin chemotherapy in the management of surgically excised anal sac apocrine gland adenocarcinoma in dogs. Vet Comp Oncol. 2016;14(1):67-80.
Skorupski KA, Alarcon CN, de Lorimier LP, LaDouceur EEB, Rodriguez CO, Rebhun RB. Outcome and clinical, pathological, and immunohistochemical factors associated with prognosis for dogs with early-stage anal sac adenocarcinoma treated with surgery alone: 34 cases (2002-2013). J Am Vet Med Assoc. 2018;253(1):84-91.
Potanas CP, Padgett S, Gamblin RM. Surgical excision of anal sac apocrine gland adenocarcinomas with and without adjunctive chemotherapy in dogs: 42 cases (2005-2011). J Am Vet Med Assoc. 2015;246(8):877-884.
Bennett PF, DeNicola DB, Bonney P, Glickman NW, Knapp DW. Canine anal sac adenocarcinomas: clinical presentation and response to therapy. J Vet Intern Med. 2002;16(1):100-104.
Polton GA, Brearley MJ. Clinical stage, therapy, and prognosis in canine anal sac gland carcinoma. J Vet Intern Med. 2007;21(2):274-280.
Anderson CL, MacKay CS, Roberts GD, Fidel J. Comparison of abdominal ultrasound and magnetic resonance imaging for detection of abdominal lymphadenopathy in dogs with metastatic apocrine gland adenocarcinoma of the anal sac. Vet Comp Oncol. 2015;13(2):98-105.
Palladino S, Keyerleber MA, King RG, Burgess KE. Utility of computed tomography versus abdominal ultrasound Eexamination to identify iliosacral lymphadenomegaly in dogs with apocrine gland adenocarcinoma of the anal sac. J Vet Intern Med. 2016;30(6):1858-1863.
Pollard RE, Fuller MC, Steffey MA. Ultrasound and computed tomography of the iliosacral lymphatic centre in dogs with anal sac gland carcinoma. Vet Comp Oncol. 2017;15(2):299-306.
Wong H, Byrne S, Rasotto R, et al. A retrospective study of clinical and histopathological features of 81 cases of canine apocrine gland adenocarcinoma of the anal sac: independent clinical and histopathological risk factors associated with outcome. Animals (Basel). 2021;11(11):1-16.
Schlag AN, Johnson T, Vinayak A, Kuvaldina A, Skinner OT, Wustefeld-Janssens BG. Comparison of methods to determine primary tumour size in canine apocrine gland anal sac adenocarcinoma. J Small Anim Pract. 2020;61(3):185-189.
Nguyen SM, Thamm DH, Vail DM, London CA. Response evaluation criteria for solid tumours in dogs (v1.0): a Veterinary Cooperative Oncology Group (VCOG) consensus document. Vet Comp Oncol. 2015;13(3):176-183.
Pradel J, Berlato D, Dobromylskyj M, Rasotto R. Prognostic significance of histopathology in canine anal sac gland adenocarcinomas: preliminary results in a retrospective study of 39 cases. Vet Comp Oncol. 2018;16(4):518-528.
Polton GA, Mowat V, Lee HC, McKee KA, Scase TJ. Breed, gender and neutering status of British dogs with anal sac gland carcinoma. Vet Comp Oncol. 2006;4(3):125-131.