Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes.
Journal
Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035
Informations de publication
Date de publication:
03 Mar 2023
03 Mar 2023
Historique:
received:
23
01
2023
accepted:
22
02
2023
revised:
19
02
2023
entrez:
2
3
2023
pubmed:
3
3
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders. We recently reported that RFX7 responds to p53 signaling and cellular stress. Furthermore, we found RFX7 target genes to be dysregulated in numerous cancer types also beyond the hematological system. However, our understanding of RFX7's target gene network and its role in health and disease remains limited. Here, we generated RFX7 knock-out cells and employed a multi-omics approach integrating transcriptome, cistrome, and proteome data to obtain a more comprehensive picture of RFX7 targets. We identify novel target genes linked to RFX7's tumor suppressor function and underscoring its potential role in neurological disorders. Importantly, our data reveal RFX7 as a mechanistic link that enables the activation of these genes in response to p53 signaling.
Identifiants
pubmed: 36864036
doi: 10.1038/s41420-023-01378-1
pii: 10.1038/s41420-023-01378-1
pmc: PMC9981735
doi:
Types de publication
Journal Article
Langues
eng
Pagination
80Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : FI 1993/2-1
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : HO 5281/7-1
Organisme : Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)
ID : 031L016D
Informations de copyright
© 2023. The Author(s).
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