Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes.
ATP production
Trypanosoma
carnitine/acylcarnitine translocation
glycolytic metabolites
metabolomics
mode of inhibition
phosphofructokinase
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
12
2022
accepted:
26
01
2023
entrez:
3
3
2023
pubmed:
4
3
2023
medline:
7
3
2023
Statut:
epublish
Résumé
Previously, we reported the development of novel small molecules that are potent inhibitors of the glycolytic enzyme phosphofructokinase (PFK) of
Identifiants
pubmed: 36864883
doi: 10.3389/fcimb.2023.1129791
pmc: PMC9971811
doi:
Substances chimiques
Phosphofructokinases
EC 2.7.1 -
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1129791Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Informations de copyright
Copyright © 2023 Nare, Moses, Burgess, Schnaufer, Walkinshaw and Michels.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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