CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
04 Mar 2023
04 Mar 2023
Historique:
pubmed:
4
3
2023
medline:
4
3
2023
entrez:
3
3
2023
Statut:
epublish
Résumé
Though the CXCR2 chemokine receptor is known to play a key role in cancer growth and response to therapy, a direct link between expression of CXCR2 in tumor progenitor cells during induction of tumorigenesis has not been established. To characterize the role of CXCR2 during melanoma tumorigenesis, we generated tamoxifen-inducible tyrosinase-promoter driven Genetic loss of Here, we provide novel mechanistic insight revealing how loss of
Sections du résumé
Background
UNASSIGNED
Though the CXCR2 chemokine receptor is known to play a key role in cancer growth and response to therapy, a direct link between expression of CXCR2 in tumor progenitor cells during induction of tumorigenesis has not been established.
Methods
UNASSIGNED
To characterize the role of CXCR2 during melanoma tumorigenesis, we generated tamoxifen-inducible tyrosinase-promoter driven
Results
UNASSIGNED
Genetic loss of
Conclusions
UNASSIGNED
Here, we provide novel mechanistic insight revealing how loss of
Identifiants
pubmed: 36865260
doi: 10.1101/2023.02.22.529548
pmc: PMC9980137
pii:
doi:
Types de publication
Preprint
Langues
eng
Commentaires et corrections
Type : UpdateIn