Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review.
antibiotic stewardship
antibiotics
gut dysbiosis
intestinal microbiome
necrotizing entercolitis
postnatal intestinal adaptation
prematurity
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
11
2022
accepted:
24
01
2023
entrez:
3
3
2023
pubmed:
4
3
2023
medline:
4
3
2023
Statut:
epublish
Résumé
While prompt initiation of antibiotics at birth due to concerns for early onset sepsis is common, it often leads to many preterm infants being exposed to treatment despite negative blood cultures. Such exposure to early antibiotics can impact the developing gut microbiome putting infants at increased risk of several diseases. Necrotizing enterocolitis (NEC), a devastating inflammatory bowel disease that affects preterm infants, is among the most widely studied neonatal disease that has been linked to early antibiotics. While some studies have demonstrated an increased risk of NEC, other studies have demonstrated seemingly contrary findings of decreased NEC with early antibiotics. Studies using animal models have also yielded differing findings of benefit vs. harm of early antibiotic exposure on subsequent NEC susceptibility. We thus sought to conduct this narrative review to help clarify the relationship between early antibiotics exposure and future risk of NEC in preterm infants. Our objectives are to: (1) summarize findings from human and animal studies that investigated the relationship between early antibiotics and NEC, (2) highlight important limitations of these studies, (3) explore potential mechanisms that can explain why early antibiotics may increase or decrease NEC risk, and (4) identify future directions for research.
Identifiants
pubmed: 36865691
doi: 10.3389/fped.2023.1112812
pmc: PMC9971631
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1112812Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK125735
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117296
Pays : United States
Informations de copyright
© 2023 Cuna, Morowitz and Sampath.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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