Whole genome sequencing of Malaysian colorectal cancer patients reveals specific druggable somatic mutations.
KDM4E
MUC16
Malaysians colorectal cancer
POTED
RNF43
druggable alterations
precision medicine
whole genome sequencing
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
07
2022
accepted:
20
09
2022
entrez:
3
3
2023
pubmed:
4
3
2023
medline:
4
3
2023
Statut:
epublish
Résumé
The incidences of colorectal cancer (CRC) are continuously increasing in some areas of the world, including Malaysia. In this study, we aimed to characterize the landscape of somatic mutations using the whole-genome sequencing approach and identify druggable somatic mutations specific to Malaysian patients. Whole-genome sequencing was performed on the genomic DNA obtained from 50 Malaysian CRC patients' tissues. We discovered the top significantly mutated genes were APC, TP53, KRAS, TCF7L2 and ACVR2A. Four novel, non-synonymous variants were identified in three genes, which were KDM4E, MUC16 and POTED. At least one druggable somatic alteration was identified in 88% of our patients. Among them were two frameshift mutations in
Identifiants
pubmed: 36866106
doi: 10.3389/fmolb.2022.997747
pii: 997747
pmc: PMC9972984
doi:
Types de publication
Journal Article
Langues
eng
Pagination
997747Informations de copyright
Copyright © 2023 Mohd Yunos, Ab Mutalib, Khoo, Saidin, Ishak, Syafruddin, Tieng, Md Yusof, Abd Razak, Mahamad Nadzir, Abu, Rose, Sagap, Mazlan and Jamal.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Cell Dev Biol. 2022 Feb 02;9:790129
pubmed: 35186950
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
World J Clin Cases. 2021 Jun 16;9(17):4143-4158
pubmed: 34141777
Mol Cancer. 2014 May 29;13:129
pubmed: 24886523
Transl Oncol. 2021 Oct;14(10):101174
pubmed: 34243011
Cancer Discov. 2011 Oct;1(5):391-407
pubmed: 22096659
Toxicol Pathol. 2014 Jan;42(1):124-39
pubmed: 24178577
Nat Rev Drug Discov. 2013 Jun;12(6):433-46
pubmed: 23722346
Nat Commun. 2022 Jun 8;13(1):3181
pubmed: 35676246
Cancer Discov. 2019 Oct;9(10):1358-1371
pubmed: 31337618
Mol Cancer Ther. 2020 Mar;19(3):765-776
pubmed: 31907221
PLoS One. 2018 Aug 30;13(8):e0200916
pubmed: 30161129
Healthcare (Basel). 2016 Jan 08;4(1):
pubmed: 27417594
Adv Exp Med Biol. 2015;867:229-44
pubmed: 26530369
Am J Cancer Res. 2013 Jun 20;3(3):278-89
pubmed: 23841027
Front Med (Lausanne). 2022 Feb 08;9:836892
pubmed: 35211490
JAMA Oncol. 2018 Dec 1;4(12):1691-1698
pubmed: 30098163
Nat Rev Clin Oncol. 2020 Jan;17(1):11-32
pubmed: 31289352
BMC Med Genomics. 2014 Feb 19;7:11
pubmed: 24552141
Front Pharmacol. 2017 Oct 12;8:736
pubmed: 29075194
J Natl Compr Canc Netw. 2017 Feb;15(2):142-147
pubmed: 28188185
Nat Biotechnol. 2013 Mar;31(3):213-9
pubmed: 23396013
Bioinformatics. 2010 Mar 1;26(5):589-95
pubmed: 20080505
Onco Targets Ther. 2020 Oct 29;13:11059-11070
pubmed: 33149618
N Engl J Med. 2015 Jun 25;372(26):2509-20
pubmed: 26028255
Cancer Res. 2013 May 15;73(10):2936-42
pubmed: 23644528
JAMA Oncol. 2019 Oct 1;5(10):1504-1506
pubmed: 31415061
Oncogene. 2020 Apr;39(17):3458-3472
pubmed: 32103169
Cell Death Dis. 2019 Nov 13;10(11):863
pubmed: 31723122
Tumour Biol. 2019 Jul;41(7):1010428319860728
pubmed: 31264534
Mol Cell Ther. 2014 Sep 11;2:28
pubmed: 26056595
Cell. 2017 Feb 9;168(4):644-656
pubmed: 28187286
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Annu Rev Physiol. 2008;70:431-57
pubmed: 17850209
Epidemiol Health. 2016 Mar 09;38:e2016007
pubmed: 26971697
J Clin Pathol. 2018 Jan;71(1):1-6
pubmed: 29018044
EXCLI J. 2018 Jan 22;17:159-168
pubmed: 29743854
Am J Cancer Res. 2015 Mar 15;5(4):1519-30
pubmed: 26101715
Nature. 2020 Feb;578(7793):82-93
pubmed: 32025007
Aging (Albany NY). 2019 Dec 10;11(23):11224-11243
pubmed: 31822636
Nat Protoc. 2008;3(6):1101-8
pubmed: 18546601
PLoS One. 2012;7(9):e45831
pubmed: 23049873
Epigenetics. 2019 Feb;14(2):185-197
pubmed: 30764732
Nucleic Acids Res. 2010 Sep;38(16):e164
pubmed: 20601685
Front Oncol. 2021 Oct 28;11:750315
pubmed: 34778065
Nature. 2010 Apr 15;464(7291):993-8
pubmed: 20393554
Oncogene. 2019 Oct;38(40):6662-6677
pubmed: 31391551
Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12649-54
pubmed: 23847203
Oncoimmunology. 2018 Aug 6;7(10):e1487914
pubmed: 30288353
World J Surg Oncol. 2022 Mar 26;20(1):95
pubmed: 35346226
Gut. 2017 Apr;66(4):683-691
pubmed: 26818619
Cells. 2019 Aug 03;8(8):
pubmed: 31382613
Cell. 2006 May 19;125(4):691-702
pubmed: 16677698
Am J Transl Res. 2022 Feb 15;14(2):849-862
pubmed: 35273689
Dig Dis Sci. 2022 Jun;67(6):2195-2208
pubmed: 33982216
Acta Pharm Sin B. 2019 Sep;9(5):871-879
pubmed: 31649840
Methods Mol Biol. 2021;2324:319-337
pubmed: 34165724
Cell. 2012 Jun 8;149(6):1192-205
pubmed: 22682243
Genome Med. 2018 Mar 28;10(1):25
pubmed: 29592813
Clin Cancer Res. 2015 Apr 15;21(8):1797-801
pubmed: 25878360
Cancer Med. 2019 Jul;8(8):3738-3747
pubmed: 31127692
Nat Rev Cancer. 2014 Feb;14(2):135-46
pubmed: 24457417
Lancet Oncol. 2017 Sep;18(9):1182-1191
pubmed: 28734759
Cancer Manag Res. 2019 Aug 07;11:7525-7536
pubmed: 31616176
Mol Cancer Ther. 2017 Apr;16(4):752-762
pubmed: 28179481
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
Biomolecules. 2020 Mar 20;10(3):
pubmed: 32245111
Oncotarget. 2016 Oct 25;7(43):70589-70600
pubmed: 27661107
Nature. 2001 Feb 15;409(6822):860-921
pubmed: 11237011
Cancer Res. 2020 Dec 15;80(24):5619-5632
pubmed: 33067269
Front Pharmacol. 2017 Jul 18;8:465
pubmed: 28769798
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Nat Genet. 2014 Dec;46(12):1264-6
pubmed: 25344691
Prog Biophys Mol Biol. 2015 Sep;118(3):112-8
pubmed: 25937466
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9
pubmed: 24277854
Cancers (Basel). 2020 Dec 11;12(12):
pubmed: 33322519
Oncol Ther. 2019 Jun;7(1):1-32
pubmed: 32700193
JAMA Netw Open. 2020 Aug 3;3(8):e2013201
pubmed: 32845327
Biomed Pharmacother. 2019 Feb;110:473-481
pubmed: 30530050
Genome Med. 2016 Dec 22;8(1):136
pubmed: 28007036
J Transl Med. 2020 Aug 28;18(1):324
pubmed: 32859214
Brief Bioinform. 2013 Mar;14(2):178-92
pubmed: 22517427
Mol Cancer Ther. 2013 Jan;12(1):94-103
pubmed: 23136185
Sci Rep. 2022 Apr 29;12(1):7013
pubmed: 35487932
J Hematol Oncol. 2020 Dec 4;13(1):165
pubmed: 33276800
Sci Rep. 2019 Dec 6;9(1):18557
pubmed: 31811196
Cell Physiol Biochem. 2015;36(5):1835-46
pubmed: 26184844