SLC26A9 in airways and intestine: secretion or absorption?
Anoctamin
SLC26A9
asthma
cystic fibrosis
epithelial transport
inflammatory airway disease
Journal
Channels (Austin, Tex.)
ISSN: 1933-6969
Titre abrégé: Channels (Austin)
Pays: United States
ID NLM: 101321614
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
entrez:
3
3
2023
pubmed:
4
3
2023
medline:
7
3
2023
Statut:
ppublish
Résumé
SLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the respiratory system, in male tissues and in the skin. SLC26A9 has gained attention because of its modifier role in the gastrointestinal manifestation of cystic fibrosis (CF). SLC26A9 appears to have an impact on the extent of intestinal obstruction caused by meconium ileus. SLC26A9 supports duodenal bicarbonate secretion, but was assumed to provide a basal Cl- secretory pathway in airways. However, recent results show that basal airway Cl- secretion is due to cystic fibrosis conductance regulator (CFTR), while SLC26A9 may rather secrete HCO
Identifiants
pubmed: 36866602
doi: 10.1080/19336950.2023.2186434
pmc: PMC9988340
doi:
Substances chimiques
Sulfate Transporters
0
Antiporters
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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