Coronary Inflammation and Plaque Vulnerability: A Coronary Computed Tomography and Optical Coherence Tomography Study.
Humans
Male
Acute Coronary Syndrome
Angina, Stable
/ diagnostic imaging
Computed Tomography Angiography
/ methods
Coronary Angiography
/ methods
Coronary Artery Disease
/ diagnostic imaging
Coronary Vessels
/ diagnostic imaging
Inflammation
/ diagnostic imaging
Plaque, Atherosclerotic
Tomography, Optical Coherence
/ methods
acute coronary syndrome
atherosclerotic plaque
computed tomography angiography
optical coherence tomography
risk stratification
Journal
Circulation. Cardiovascular imaging
ISSN: 1942-0080
Titre abrégé: Circ Cardiovasc Imaging
Pays: United States
ID NLM: 101479935
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
pubmed:
4
3
2023
medline:
24
3
2023
entrez:
3
3
2023
Statut:
ppublish
Résumé
Vascular inflammation plays a key role in atherogenesis and in the development of acute coronary syndromes. Coronary inflammation can be measured by peri-coronary adipose tissue (PCAT) attenuation on computed tomography angiography. We examined the relationships between the level of coronary artery inflammation assessed by PCAT attenuation and coronary plaque characteristics by optical coherence tomography. A total of 474 patients (198 acute coronary syndromes and 276 stable angina pectoris) who underwent preintervention coronary computed tomography angiography and optical coherence tomography were included. To compare the relationships between the level of coronary artery inflammation and detailed plaque characteristics, we divided the subjects into high (n=244) and low (n=230) PCAT attenuation groups using a threshold value of -70.1 Hounsfield units. The high PCAT attenuation group, compared with the low PCAT attenuation group, had more males (90.6% versus 69.6%; Optical coherence tomography features of plaque vulnerability were significantly more common in patients with high PCAT attenuation, compared with those with low PCAT attenuation. Vascular inflammation and plaque vulnerability are intimately related in patients with coronary artery disease. URL: https://www. gov; Unique identifier: NCT04523194.
Sections du résumé
BACKGROUND
Vascular inflammation plays a key role in atherogenesis and in the development of acute coronary syndromes. Coronary inflammation can be measured by peri-coronary adipose tissue (PCAT) attenuation on computed tomography angiography. We examined the relationships between the level of coronary artery inflammation assessed by PCAT attenuation and coronary plaque characteristics by optical coherence tomography.
METHODS
A total of 474 patients (198 acute coronary syndromes and 276 stable angina pectoris) who underwent preintervention coronary computed tomography angiography and optical coherence tomography were included. To compare the relationships between the level of coronary artery inflammation and detailed plaque characteristics, we divided the subjects into high (n=244) and low (n=230) PCAT attenuation groups using a threshold value of -70.1 Hounsfield units.
RESULTS
The high PCAT attenuation group, compared with the low PCAT attenuation group, had more males (90.6% versus 69.6%;
CONCLUSIONS
Optical coherence tomography features of plaque vulnerability were significantly more common in patients with high PCAT attenuation, compared with those with low PCAT attenuation. Vascular inflammation and plaque vulnerability are intimately related in patients with coronary artery disease.
REGISTRATION
URL: https://www.
CLINICALTRIALS
gov; Unique identifier: NCT04523194.
Identifiants
pubmed: 36866660
doi: 10.1161/CIRCIMAGING.122.014959
doi:
Banques de données
ClinicalTrials.gov
['NCT04523194']
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e014959Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL151266
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148787
Pays : United States