Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10

Animals Mice Colitis / virology Disease Models, Animal Dysbiosis / virology Inflammatory Bowel Diseases / virology Interleukin-10 Mammary Tumor Virus, Mouse Mice, Inbred C3H
Inflammatory bowel disease Interleukin-10 knockout mouse Mouse mammary tumor virus

Journal

Microbiome
ISSN: 2049-2618
Titre abrégé: Microbiome
Pays: England
ID NLM: 101615147

Informations de publication

Date de publication:
03 03 2023
Historique:
received: 25 02 2022
accepted: 30 01 2023
entrez: 3 3 2023
pubmed: 4 3 2023
medline: 8 3 2023
Statut: epublish

Résumé

Following viral infection, genetically manipulated mice lacking immunoregulatory function may develop colitis and dysbiosis in a strain-specific fashion that serves as a model for inflammatory bowel disease (IBD). We found that one such model of spontaneous colitis, the interleukin (IL)-10 knockout (IL-10 Viral preparations extracted from IL-10 This study suggests that immunogenetically manipulated mice with deletion of IL-10 may have reduced capacity to contain MMTV infection in a mouse-strain-specific manner, and the antiviral inflammatory responses may contribute to the complexity of IBD with the development of colitis and dysbiosis. Video Abstract.

Sections du résumé

BACKGROUND
Following viral infection, genetically manipulated mice lacking immunoregulatory function may develop colitis and dysbiosis in a strain-specific fashion that serves as a model for inflammatory bowel disease (IBD). We found that one such model of spontaneous colitis, the interleukin (IL)-10 knockout (IL-10
RESULTS
Viral preparations extracted from IL-10
CONCLUSIONS
This study suggests that immunogenetically manipulated mice with deletion of IL-10 may have reduced capacity to contain MMTV infection in a mouse-strain-specific manner, and the antiviral inflammatory responses may contribute to the complexity of IBD with the development of colitis and dysbiosis. Video Abstract.

Identifiants

DOI: 10.1186/s40168-023-01483-4 PMID: 36869359 PMC: PMC9983191
pubmed: 36869359
doi: 10.1186/s40168-023-01483-4
pii: 10.1186/s40168-023-01483-4
pmc: PMC9983191
doi:

Substances chimiques

Interleukin-10 130068-27-8

Types de publication

Video-Audio Media Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

39

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

© 2023. The Author(s).

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Auteurs

Heather Armstrong (H)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.

Mandana Rahbari (M)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Medicine, University of Alberta, Edmonton, Canada.

Heekuk Park (H)

Columbia University, New York, USA.

David Sharon (D)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Medicine, University of Alberta, Edmonton, Canada.

Aducio Thiesen (A)

Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, Canada.

Naomi Hotte (N)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Medicine, University of Alberta, Edmonton, Canada.

Ning Sun (N)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Medicine, University of Alberta, Edmonton, Canada.
Li Ka Shing Institute for Virology, University of Alberta, Edmonton, Canada.

Hussain Syed (H)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Medicine, University of Alberta, Edmonton, Canada.
Li Ka Shing Institute for Virology, University of Alberta, Edmonton, Canada.

Hiatem Abofayed (H)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Medicine, University of Alberta, Edmonton, Canada.
Li Ka Shing Institute for Virology, University of Alberta, Edmonton, Canada.

Weiwei Wang (W)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Medicine, University of Alberta, Edmonton, Canada.

Karen Madsen (K)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Medicine, University of Alberta, Edmonton, Canada.

Eytan Wine (E)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada.
Department of Physiology, University of Alberta, Edmonton, Canada.
Department of Pediatrics, University of Alberta, Edmonton, Canada.

Andrew Mason (A)

Center of Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Canada. andrew.mason@ualberta.ca.
Department of Medicine, University of Alberta, Edmonton, Canada. andrew.mason@ualberta.ca.
Li Ka Shing Institute for Virology, University of Alberta, Edmonton, Canada. andrew.mason@ualberta.ca.
Division of Gastroenterology, University of Alberta, Edmonton, AB, T6G 2E1, Canada. andrew.mason@ualberta.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mouse mammary tumor virus is implicated in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mouse mammary tumor virus is implicated in...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Mouse mammary tumor virus is implicated in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Mouse mammary tumor virus is implicated in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dysbiose › Mouse mammary tumor virus is implicated in...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Mouse mammary tumor virus is implicated in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › Mouse mammary tumor virus is implicated in...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Betaretrovirus › Virus de la tumeur mammaire de la souris › Mouse mammary tumor virus is implicated in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C3H › Mouse mammary tumor virus is implicated in...