Clinicopathological associations of hemispheric dominance in primary progressive apraxia of speech.
DAT scan
FDG-PET
PPAOS
premotor
supplementary motor area
Journal
European journal of neurology
ISSN: 1468-1331
Titre abrégé: Eur J Neurol
Pays: England
ID NLM: 9506311
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
revised:
24
02
2023
received:
16
01
2023
accepted:
27
02
2023
medline:
6
4
2023
pubmed:
5
3
2023
entrez:
4
3
2023
Statut:
ppublish
Résumé
Primary progressive apraxia of speech (PPAOS) is associated with imaging abnormalities in the lateral premotor cortex (LPC) and supplementary motor area (SMA). It is not known whether greater involvement of these regions in either hemisphere is associated with demographics, presenting, and/or longitudinal features. In 51 prospectively recruited PPAOS patients who completed [ In all, 49% of the PPAOS patients were classified as left-dominant, 31% as right-dominant, and 20% as symmetric, which was supported by results from the SPM and regional analyses. There were no differences in baseline characteristics. Longitudinally, right-dominant PPAOS showed faster rates of progression of ideomotor apraxia (AUROC 0.79), behavioral disturbances (AUROC 0.84), including disinhibition symptoms (AUROC 0.82) and negative behaviors (AUROC 0.82), and parkinsonism (AUROC 0.75) compared to left-dominant PPAOS. Symmetric PPAOS showed faster rates of dysarthria progression compared to left-dominant (AUROC 0.89) and right-dominant PPAOS (AUROC 0.79). Five patients showed abnormal DAT uptake. Braak neurofibrillary tangle stage differed across groups (p = 0.01). Patients with PPAOS and a right-dominant pattern of hypometabolism on FDG-PET have the fastest rates of decline of behavioral and motor features.
Identifiants
pubmed: 36869612
doi: 10.1111/ene.15764
pmc: PMC10410644
mid: NIHMS1919550
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1209-1219Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC012519
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014942
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS089757
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG074879
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2023 European Academy of Neurology.
Références
Alzheimers Dement. 2014 Nov;10(6):630-6
pubmed: 24985533
J Neurol. 2011 Apr;258(4):549-58
pubmed: 21181185
Am J Speech Lang Pathol. 2018 Nov 21;27(4):1303-1318
pubmed: 30458509
Neurocase. 2014;20(1):46-52
pubmed: 23058062
Am J Speech Lang Pathol. 2020 Nov 12;29(4):1976-1986
pubmed: 32755493
Brain. 2006 Jun;129(Pt 6):1385-98
pubmed: 16613895
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Cerebrovasc Dis. 2007;23(5-6):331-8
pubmed: 17268163
Am J Alzheimers Dis Other Demen. 2009 Oct-Nov;24(5):408-16
pubmed: 19700669
Continuum (Minneap Minn). 2019 Feb;25(1):101-127
pubmed: 30707189
Neurology. 2010 Jan 5;74(1):42-9
pubmed: 19940270
Neurology. 2002 Jun 25;58(12):1791-800
pubmed: 12084879
J Mol Neurosci. 2011 Nov;45(3):384-9
pubmed: 21720721
J Neurol. 2020 Sep;267(9):2603-2611
pubmed: 32388831
N Engl J Med. 2003 Oct 16;349(16):1535-42
pubmed: 14561797
Arch Neurol. 2004 Dec;61(12):1881-4
pubmed: 15596608
Neurology. 1991 Apr;41(4):479-86
pubmed: 2011243
Neurology. 2001 Jun;56(11 Suppl 4):S16-20
pubmed: 11402145
Can J Neurol Sci. 1997 Feb;24(1):29-36
pubmed: 9043744
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Neurology. 2022 Aug 2;99(5):e500-e511
pubmed: 35914945
Neuroimage Clin. 2018 Mar 03;18:617-629
pubmed: 29845010
Neurology. 2013 Jul 23;81(4):337-45
pubmed: 23803320
Am J Speech Lang Pathol. 2015 May;24(2):88-100
pubmed: 25654422
Neurology. 1994 Nov;44(11):2015-9
pubmed: 7969952
J Speech Lang Hear Res. 2012 Oct;55(5):S1518-22
pubmed: 23033445
Behav Neurol. 2007;18(4):239-43
pubmed: 18430983
Mov Disord. 2008 Nov 15;23(15):2129-70
pubmed: 19025984
J Nucl Med. 1995 Jul;36(7):1238-48
pubmed: 7790950
J Alzheimers Dis. 2020;74(1):377-389
pubmed: 32039841
J Commun Disord. 2014 Sep-Oct;51:43-50
pubmed: 25092638
J Nucl Med. 2019 Dec;60(12):1757-1763
pubmed: 30979821
Nat Commun. 2021 Jun 8;12(1):3452
pubmed: 34103532
Brain. 2014 Oct;137(Pt 10):2783-95
pubmed: 25113789
Curr Opin Neurol. 2008 Dec;21(6):688-92
pubmed: 18989114
Ann Neurol. 1982 Jun;11(6):592-8
pubmed: 7114808
J Neuropathol Exp Neurol. 2002 Nov;61(11):935-46
pubmed: 12430710
Aphasiology. 2021;35(4):560-591
pubmed: 34219857
Front Neurol. 2021 Feb 17;12:615024
pubmed: 33679582
Neuroimage Clin. 2022;34:102999
pubmed: 35395498
Brain. 2012 May;135(Pt 5):1522-36
pubmed: 22382356
Neurocase. 2018 Apr;24(2):111-120
pubmed: 29799310
Brain Lang. 2018 Sep;184:54-65
pubmed: 29980072
Eur J Neurol. 2014 Mar;21(3):368-76
pubmed: 24053325
J Neuropsychiatry Clin Neurosci. 2000 Spring;12(2):233-9
pubmed: 11001602
J Neurol. 2015 Oct;262(10):2336-45
pubmed: 26194195