Immunogenicity and protective activity of mRNA vaccine candidates against yellow fever virus in animal models.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
04 Mar 2023
04 Mar 2023
Historique:
received:
15
07
2022
accepted:
17
02
2023
entrez:
4
3
2023
pubmed:
5
3
2023
medline:
5
3
2023
Statut:
epublish
Résumé
Despite the success of the widely used attenuated yellow fever (YF) vaccine, its global supply remains a substantial barrier to implementing vaccination campaigns in endemic regions and combating emerging epidemics. In A129 mice and rhesus macaques, we evaluated the immunogenicity and protective activity of messenger RNA (mRNA) vaccine candidates encapsulated in lipid nanoparticles, expressing the pre-membrane and envelope proteins or the non-structural protein 1 of YF virus. Vaccine constructs induced humoral and cell-mediated immune responses in mice, resulting in protection against lethal YF virus infection after passive administration of serum or splenocytes from vaccinated mice. Vaccination of macaques induced sustained high humoral and cellular immune responses for at least 5 months after the second dose. Our data demonstrate that these mRNA vaccine candidates can be considered an attractive addition to the licensed YF vaccine supply based on the induction of functional antibodies correlating with protection and T-cell responses; they could alleviate the limited supply of current YF vaccines, mitigating future YF epidemics.
Identifiants
pubmed: 36871059
doi: 10.1038/s41541-023-00629-7
pii: 10.1038/s41541-023-00629-7
pmc: PMC9984760
doi:
Types de publication
Journal Article
Langues
eng
Pagination
31Informations de copyright
© 2023. The Author(s).
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