Chemical modification by peroxynitrite enhances TLR4 activation of the grass pollen allergen Phl p 5.
Bet v 1
Phl p 5
air pollution
allergy
dimers
nitration
oligomers
peroxynitrite
Journal
Frontiers in allergy
ISSN: 2673-6101
Titre abrégé: Front Allergy
Pays: Switzerland
ID NLM: 9918227355906676
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
10
2022
accepted:
12
01
2023
entrez:
6
3
2023
pubmed:
7
3
2023
medline:
7
3
2023
Statut:
epublish
Résumé
The chemical modification of aeroallergens by reactive oxygen and nitrogen species (ROS/RNS) may contribute to the growing prevalence of respiratory allergies in industrialized countries. Post-translational modifications can alter the immunological properties of proteins, but the underlying mechanisms and effects are not well understood. In this study, we investigate the Toll-like receptor 4 (TLR4) activation of the major birch and grass pollen allergens Bet v 1 and Phl p 5, and how the physiological oxidant peroxynitrite (ONOO
Identifiants
pubmed: 36873048
doi: 10.3389/falgy.2023.1066392
pmc: PMC9975604
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1066392Informations de copyright
© 2023 Reinmuth-Selzle, Bellinghausen, Leifke, Backes, Bothen, Ziegler, Weller, Saloga, Schuppan, Lucas, Pöschl and Fröhlich-Nowoisky.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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