Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators.

Bioisosteres Drug discovery Healthy aging Medicinal chemistry Nicotinamide phosphoribosyl transferase activator

Journal

Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560

Informations de publication

Date de publication:
Feb 2023
Historique:
received: 18 05 2022
revised: 22 06 2022
accepted: 13 07 2022
entrez: 6 3 2023
pubmed: 7 3 2023
medline: 7 3 2023
Statut: ppublish

Résumé

The cofactor nicotinamide adenine dinucleotide (NAD

Identifiants

pubmed: 36873168
doi: 10.1016/j.apsb.2022.07.016
pii: S2211-3835(22)00328-8
pmc: PMC9978853
doi:

Types de publication

Journal Article

Langues

eng

Pagination

709-721

Informations de copyright

© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

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Auteurs

Siyuan Tang (S)

Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PL, UK.

Miguel Garzon Sanz (M)

Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PL, UK.

Oliver Smith (O)

Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PL, UK.

Andreas Krämer (A)

Structural Genomics Consortium (SGC), 60438 Frankfurt Am Main, Germany.
Buchmann Institute for Life Sciences (BMLS), 60438 Frankfurt Am Main, Germany.
Institut für Pharmazeutische Chemie, Goethe University, 60438 Frankfurt Am Main, Germany.
Frankfurt Cancer Institute (FCI), 60596 Frankfurt Am Main, Germany.

Daniel Egbase (D)

Department of Diabetes, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 1UL, UK.

Paul W Caton (PW)

Department of Diabetes, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 1UL, UK.

Stefan Knapp (S)

Structural Genomics Consortium (SGC), 60438 Frankfurt Am Main, Germany.
Buchmann Institute for Life Sciences (BMLS), 60438 Frankfurt Am Main, Germany.
Institut für Pharmazeutische Chemie, Goethe University, 60438 Frankfurt Am Main, Germany.
Frankfurt Cancer Institute (FCI), 60596 Frankfurt Am Main, Germany.

Sam Butterworth (S)

Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PL, UK.

Classifications MeSH