Immunogenicity of CRISPR therapeutics-Critical considerations for clinical translation.
CRISPR-Cas
Cas9
clinical translation
clinical trials
gene therapy
genome editing
immunogenicity
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
01
2023
accepted:
06
02
2023
entrez:
6
3
2023
pubmed:
7
3
2023
medline:
7
3
2023
Statut:
epublish
Résumé
CRISPR offers new hope for many patients and promises to transform the way we think of future therapies. Ensuring safety of CRISPR therapeutics is a top priority for clinical translation and specific recommendations have been recently released by the FDA. Rapid progress in the preclinical and clinical development of CRISPR therapeutics leverages years of experience with gene therapy successes and failures. Adverse events due to immunogenicity have been a major setback that has impacted the field of gene therapy. As several
Identifiants
pubmed: 36873375
doi: 10.3389/fbioe.2023.1138596
pii: 1138596
pmc: PMC9978118
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1138596Informations de copyright
Copyright © 2023 Ewaisha and Anderson.
Déclaration de conflit d'intérêts
RE and KSA are noted as inventors on a patent regarding Cas9 immunity.
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