Vitamin D status in ANCA-associated vasculitis.

ANCA-associated vasculitis cohort study eosinophilic granulomatosis with polyangiitis granulomatosis with polyangiitis microscopic polyangiitis vitamin D

Journal

Rheumatology advances in practice
ISSN: 2514-1775
Titre abrégé: Rheumatol Adv Pract
Pays: England
ID NLM: 101736676

Informations de publication

Date de publication:
2023
Historique:
received: 01 12 2022
accepted: 31 01 2023
entrez: 6 3 2023
pubmed: 7 3 2023
medline: 7 3 2023
Statut: epublish

Résumé

Vitamin D might participate in the pathogenesis of several immune-mediated diseases, but few related data are available for ANCA-associated vasculitis (AAV). In this study, we analysed the association between vitamin D status and disease in patients with AAV. Serum levels of 25(OH)D Seventy of 125 patients (56%) were female, with a mean age of 51.5 (16) years at diagnosis; 84 (67%) were ANCA positive. Mean 25(OH)D was 37.6 (16) ng/ml, with vitamin D deficiency in 13 (10.4%) and insufficiency in 26 (20.8%). In univariate analysis, lower vitamin D status was associated with male sex ( Most patients with AAV have sufficient 25(OH)D levels, although those with lower vitamin D status were more likely to be male and to have active disease. Whether optimization of vitamin D status alters disease manifestations or activity in AAV remains to be determined. Vasculitis Clinical Research Consortium (VCRC) Longitudinal Study (LS), NCT00315380, https://clinicaltrials.gov/ct2/show/NCT00315380.

Identifiants

pubmed: 36874269
doi: 10.1093/rap/rkad021
pii: rkad021
pmc: PMC9977244
doi:

Banques de données

ClinicalTrials.gov
['NCT00315380']

Types de publication

Journal Article

Langues

eng

Pagination

rkad021

Informations de copyright

© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology.

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Auteurs

Irena Doubelt (I)

Vasculitis Clinic, Mount Sinai Hospital, Department of Rheumatology, University of Toronto, Toronto, ON, Canada.

David Cuthbertson (D)

Health Informatics Institute, University of South Florida, Tampa, FL, USA.

Simon Carette (S)

Vasculitis Clinic, Mount Sinai Hospital, Department of Rheumatology, University of Toronto, Toronto, ON, Canada.

Nader A Khalidi (NA)

Division of Rheumatology, McMaster University and St. Joseph's Healthcare, Hamilton, ON, Canada.

Curry L Koening (CL)

Division of Rheumatology, University of Utah Hospital, Salt Lake City, UT, USA.

Carol Langford (C)

Division of Rheumatology, Cleveland Clinic, Cleveland, OH, USA.

Carol A McAlear (CA)

Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Larry W Moreland (LW)

Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, USA.

Paul Monach (P)

Division of Rheumatology, VA Boston Healthcare System, Boston, MA, USA.

Philip Seo (P)

Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA.

Ulrich Specks (U)

Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Kenneth J Warrington (KJ)

Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Peter A Merkel (PA)

Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Christian Pagnoux (C)

Vasculitis Clinic, Mount Sinai Hospital, Department of Rheumatology, University of Toronto, Toronto, ON, Canada.

Classifications MeSH