Massively parallel, real-time multispeckle diffuse correlation spectroscopy using a 500 × 500 SPAD camera.
Journal
Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630
Informations de publication
Date de publication:
01 Feb 2023
01 Feb 2023
Historique:
received:
25
08
2022
revised:
01
12
2022
accepted:
24
12
2022
entrez:
6
3
2023
pubmed:
7
3
2023
medline:
7
3
2023
Statut:
epublish
Résumé
Diffuse correlation spectroscopy (DCS) is a promising noninvasive technique for monitoring cerebral blood flow and measuring cortex functional activation tasks. Taking multiple parallel measurements has been shown to increase sensitivity, but is not easily scalable with discrete optical detectors. Here we show that with a large 500 × 500 SPAD array and an advanced FPGA design, we achieve an SNR gain of almost 500 over single-pixel mDCS performance. The system can also be reconfigured to sacrifice SNR to decrease correlation bin width, with 400 ns resolution being demonstrated over 8000 pixels.
Identifiants
pubmed: 36874503
doi: 10.1364/BOE.473992
pii: 473992
pmc: PMC9979680
doi:
Types de publication
Journal Article
Langues
eng
Pagination
703-713Informations de copyright
© 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.
Déclaration de conflit d'intérêts
MAW: Meta Platforms Inc. (F), EJS: Meta Platforms Inc. (E), PM: Meta Platforms Inc. (F), FM: Meta Platforms Inc. (E), EC: Fasttree3D SA (I,S) and PI Imaging Technology SA (I, S), CB: PI Imaging Technology SA (I, S).
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