The Antioxidant Activity and Induction of Apoptotic Cell Death by
Musa paradisiaca
antioxidant
apoptosis
head and neck squamous cell carcinoma
stingless bee
Journal
The Malaysian journal of medical sciences : MJMS
ISSN: 1394-195X
Titre abrégé: Malays J Med Sci
Pays: Malaysia
ID NLM: 101126308
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
13
02
2022
accepted:
29
04
2022
entrez:
6
3
2023
pubmed:
7
3
2023
medline:
7
3
2023
Statut:
ppublish
Résumé
Head and neck cancer patients usually need nutritional support due to difficulties in swallowing and chewing. Therefore, this study aimed to formulate The antioxidant properties were analysed using 2,2'-diphenyl-1 picrylhydrazyl (DPPH), ferric reducing antioxidant potential (FRAP) and 2,2'-azinodi 3-ethylbenthiazolinesulfonate (ABTS) assays. Cytotoxicity was assayed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test and the induction of apoptosis was observed via caspase-3/7 activity assay. The identification of phenolic compounds was done via ultra-high-performance-liquid chromatography coupled to mass spectrometer (UHPLC-MS/MS). The antioxidant analysis exhibited: the half inhibitory concentration (IC The study evidenced that the antioxidant activity of MTJ could influence the induction of apoptosis in ORL115 and ORL188 in future investigations and verifications.
Sections du résumé
Background
UNASSIGNED
Head and neck cancer patients usually need nutritional support due to difficulties in swallowing and chewing. Therefore, this study aimed to formulate
Methods
UNASSIGNED
The antioxidant properties were analysed using 2,2'-diphenyl-1 picrylhydrazyl (DPPH), ferric reducing antioxidant potential (FRAP) and 2,2'-azinodi 3-ethylbenthiazolinesulfonate (ABTS) assays. Cytotoxicity was assayed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test and the induction of apoptosis was observed via caspase-3/7 activity assay. The identification of phenolic compounds was done via ultra-high-performance-liquid chromatography coupled to mass spectrometer (UHPLC-MS/MS).
Results
UNASSIGNED
The antioxidant analysis exhibited: the half inhibitory concentration (IC
Conclusion
UNASSIGNED
The study evidenced that the antioxidant activity of MTJ could influence the induction of apoptosis in ORL115 and ORL188 in future investigations and verifications.
Identifiants
pubmed: 36875196
doi: 10.21315/mjms2023.30.1.7
pii: mjms3001_art7_oa
pmc: PMC9984108
doi:
Types de publication
Journal Article
Langues
eng
Pagination
82-91Informations de copyright
© Penerbit Universiti Sains Malaysia, 2023.
Déclaration de conflit d'intérêts
Conflict of Interest None.
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