Emerging roles of histone deacetylases in adaptive thermogenesis.
adaptive thermogenesis
adipose tissue
diabetes
histone deacetylase
obesity
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
15
12
2022
accepted:
07
02
2023
entrez:
6
3
2023
pubmed:
7
3
2023
medline:
8
3
2023
Statut:
epublish
Résumé
Brown and beige adipose tissues regulate body energy expenditure through adaptive thermogenesis, which converts energy into heat by oxidative phosphorylation uncoupling. Although promoting adaptive thermogenesis has been demonstrated to be a prospective strategy for obesity control, there are few methods for increasing adipose tissue thermogenesis in a safe and effective way. Histone deacetylase (HDAC) is a category of epigenetic modifying enzymes that catalyzes deacetylation on both histone and non-histone proteins. Recent studies illustrated that HDACs play an important role in adipose tissue thermogenesis through modulating gene transcription and chromatin structure as well as cellular signals transduction in both deacetylation dependent or independent manners. Given that different classes and subtypes of HDACs show diversity in the mechanisms of adaptive thermogenesis regulation, we systematically summarized the effects of different HDACs on adaptive thermogenesis and their underlying mechanisms in this review. We also emphasized the differences among HDACs in thermogenesis regulation, which will help to find new efficient anti-obesity drugs targeting specific HDAC subtypes.
Identifiants
pubmed: 36875455
doi: 10.3389/fendo.2023.1124408
pmc: PMC9978507
doi:
Substances chimiques
Anti-Obesity Agents
0
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1124408Informations de copyright
Copyright © 2023 Zhou, Cao, Xiang, Fang and Shang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17335-40
pubmed: 17956988
J Endocrinol. 2021 May 06;249(3):177-193
pubmed: 33856361
Science. 1996 Apr 19;272(5260):408-11
pubmed: 8602529
Nat Rev Endocrinol. 2020 Nov;16(11):654-667
pubmed: 32764725
Cells. 2019 Jul 30;8(8):
pubmed: 31366145
J Intern Med. 2018 Nov;284(5):492-504
pubmed: 29923291
Eur J Med Chem. 2021 Dec 15;226:113825
pubmed: 34562854
Nat Cell Biol. 2012 Jan 15;14(2):209-19
pubmed: 22246346
Int J Mol Sci. 2018 Sep 04;19(9):
pubmed: 30181511
Annu Rev Pathol. 2023 Jan 24;18:71-93
pubmed: 36070562
Curr Top Med Chem. 2018;18(28):2420-2428
pubmed: 30526462
Int J Obes (Lond). 2015 Aug;39(8):1188-96
pubmed: 25896063
J Neurosci. 2012 Dec 12;32(50):18137-49
pubmed: 23238728
Int J Mol Sci. 2018 Nov 02;19(11):
pubmed: 30400212
Sci Rep. 2018 Aug 30;8(1):13072
pubmed: 30166563
Obesity (Silver Spring). 2019 Jan;27(1):13-21
pubmed: 30569639
J Physiol Biochem. 2019 Feb;75(1):1-10
pubmed: 30506389
Nature. 1997 Sep 25;389(6649):349-52
pubmed: 9311776
Cold Spring Harb Perspect Biol. 2014 Apr 01;6(4):a018713
pubmed: 24691964
Nature. 2017 Jun 22;546(7659):544-548
pubmed: 28614293
Diabetes. 2020 Feb;69(2):165-180
pubmed: 31712319
Cell Metab. 2014 May 6;19(5):810-20
pubmed: 24709624
Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):
pubmed: 35149557
Biochem J. 2003 Mar 15;370(Pt 3):737-49
pubmed: 12429021
Diabetes. 2014 Jan;63(1):176-87
pubmed: 24101673
Cells. 2020 Jan 28;9(2):
pubmed: 32012991
Cell. 2022 Feb 3;185(3):419-446
pubmed: 35120662
Biochem Biophys Res Commun. 2018 Sep 3;503(1):285-290
pubmed: 29890133
Nat Med. 2017 Dec;23(12):1454-1465
pubmed: 29131158
Trends Endocrinol Metab. 2016 Jan;27(1):11-23
pubmed: 26688472
Drug Discov Today. 2016 Mar;21(3):499-509
pubmed: 26697737
Cell. 2012 Jul 20;150(2):366-76
pubmed: 22796012
Nat Commun. 2017 Jul 21;8(1):93
pubmed: 28733645
Trends Endocrinol Metab. 2017 Jan;28(1):19-31
pubmed: 27692461
Diabetes. 2013 Mar;62(3):732-42
pubmed: 23069623
Physiology (Bethesda). 2023 Jan 1;38(1):0
pubmed: 36125787
Obesity (Silver Spring). 2016 Mar;24(3):634-42
pubmed: 26916242
Diabetes. 2009 Jul;58(7):1509-17
pubmed: 19366864
J Biosci. 2020;45:
pubmed: 33184251
Cell Metab. 2015 Oct 6;22(4):546-59
pubmed: 26445512
Cell. 2012 Aug 3;150(3):620-32
pubmed: 22863012
Nat Rev Mol Cell Biol. 2019 Mar;20(3):156-174
pubmed: 30467427
Int J Mol Sci. 2020 Apr 24;21(8):
pubmed: 32344721
Endocrinology. 2018 Jul 1;159(7):2520-2527
pubmed: 29757434
Cell Rep. 2017 Jul 18;20(3):641-654
pubmed: 28723567
Front Endocrinol (Lausanne). 2020 Feb 27;11:95
pubmed: 32174890
Int J Obes (Lond). 2017 Feb;41(2):289-298
pubmed: 27795551
FASEB J. 2015 Jan;29(1):286-99
pubmed: 25392270
J Biol Chem. 2011 May 13;286(19):16958-66
pubmed: 21454513
J Biol Chem. 2005 Apr 8;280(14):13560-7
pubmed: 15653680
J Mol Cell Cardiol. 2019 May;130:151-159
pubmed: 30978343
Lancet Diabetes Endocrinol. 2013 Dec;1(4):353-60
pubmed: 24622420
Eur J Intern Med. 2021 Nov;93:3-7
pubmed: 33461826
Acta Pharm Sin B. 2019 Mar;9(2):220-236
pubmed: 30976490
Adipocyte. 2014 Dec 10;3(4):333-8
pubmed: 26317058
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158594
pubmed: 31904421
J Biol Chem. 2016 Feb 26;291(9):4523-36
pubmed: 26733201
Nat Rev Endocrinol. 2019 May;15(5):288-298
pubmed: 30814686
Exp Mol Med. 2021 Sep;53(9):1298-1306
pubmed: 34493807
Genes (Basel). 2020 May 15;11(5):
pubmed: 32429325
Diabetes. 2011 Mar;60(3):918-24
pubmed: 21270237
J Clin Endocrinol Metab. 2011 Jan;96(1):192-9
pubmed: 20943785
JCI Insight. 2018 Aug 9;3(15):
pubmed: 30089714
Biomed Pharmacother. 2020 May;125:109767
pubmed: 32058210
Circ Res. 2018 Sep 14;123(7):868-885
pubmed: 30355082
Int J Mol Sci. 2019 Jun 01;20(11):
pubmed: 31159462
Annu Rev Physiol. 2016;78:223-41
pubmed: 26654352
Compr Physiol. 2017 Sep 12;7(4):1281-1306
pubmed: 28915325
Mol Metab. 2020 Dec;42:101097
pubmed: 33049408
Cell. 2015 Oct 22;163(3):643-55
pubmed: 26496606
Cell. 2000 Sep 1;102(5):587-98
pubmed: 11007477
J Proteome Res. 2006 Mar;5(3):502-11
pubmed: 16512664
Biochem Biophys Res Commun. 2018 Jun 7;500(3):682-690
pubmed: 29678576
Nat Rev Endocrinol. 2019 May;15(5):274-287
pubmed: 30655624