Birth prevalence of genital anomalies among males conceived by intracytoplasmic sperm injection cycles: A cross-sectional study.
Hypospadias
Microinjections
Prevalence
Reproductive techniques
Urogenital abnormalities.
Cryptorchidism
Journal
International journal of reproductive biomedicine
ISSN: 2476-4108
Titre abrégé: Int J Reprod Biomed
Pays: Iran
ID NLM: 101679102
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
18
07
2021
revised:
13
04
2022
accepted:
13
11
2022
entrez:
6
3
2023
pubmed:
7
3
2023
medline:
7
3
2023
Statut:
epublish
Résumé
Several studies have been conducted worldwide to evaluate the prevalence and relative risks of congenital anomalies associated with assisted reproductive technology cycles; however, there is limited data in Iran. To investigate male genital anomalies among live births from assisted reproductive technology. This cross-sectional study was conducted on children born after intracytoplasmic sperm injection (ICSI) at Royan Institute, Tehran, Iran from April 2013-December 2015. The prevalence of male genitalia disorders that included hypospadias, epispadias, cryptorchidism, micropenis, and vanishing testis were reported. The relationship between the cause of infertility and type of embryo transfer (fresh or frozen), gestational age at birth (term or preterm), and birth weight with these male genitalia anomalies were evaluated. In total, 4409 pregnant women were followed after their ICSI cycles to evaluate genitalia anomalies in their children. Out of 5608 live births, 2614 (46.61%) newborns were male, of which 14 cases (0.54%) had genital anomalies. The prevalence of various anomalies were cryptorchidism (0.34%), hypospadias (0.038%), micropenis (0.038%), vanishing testis (0.038%), and epispadias (0.077%). No relationship was found between the cause of infertility, type of embryo transfer (fresh or frozen), gestational age at birth (term or preterm), and male genital malformation (p = 0.33, p = 0.66, and p = 0.62, respectively). The prevalence of each male genital anomaly after the ICSI cycle was rare and less than 0.5%; however, no significant infertility-related factor was observed with these anomalies.
Sections du résumé
Background
UNASSIGNED
Several studies have been conducted worldwide to evaluate the prevalence and relative risks of congenital anomalies associated with assisted reproductive technology cycles; however, there is limited data in Iran.
Objective
UNASSIGNED
To investigate male genital anomalies among live births from assisted reproductive technology.
Materials and Methods
UNASSIGNED
This cross-sectional study was conducted on children born after intracytoplasmic sperm injection (ICSI) at Royan Institute, Tehran, Iran from April 2013-December 2015. The prevalence of male genitalia disorders that included hypospadias, epispadias, cryptorchidism, micropenis, and vanishing testis were reported. The relationship between the cause of infertility and type of embryo transfer (fresh or frozen), gestational age at birth (term or preterm), and birth weight with these male genitalia anomalies were evaluated.
Results
UNASSIGNED
In total, 4409 pregnant women were followed after their ICSI cycles to evaluate genitalia anomalies in their children. Out of 5608 live births, 2614 (46.61%) newborns were male, of which 14 cases (0.54%) had genital anomalies. The prevalence of various anomalies were cryptorchidism (0.34%), hypospadias (0.038%), micropenis (0.038%), vanishing testis (0.038%), and epispadias (0.077%). No relationship was found between the cause of infertility, type of embryo transfer (fresh or frozen), gestational age at birth (term or preterm), and male genital malformation (p = 0.33, p = 0.66, and p = 0.62, respectively).
Conclusion
UNASSIGNED
The prevalence of each male genital anomaly after the ICSI cycle was rare and less than 0.5%; however, no significant infertility-related factor was observed with these anomalies.
Identifiants
pubmed: 36875504
doi: 10.18502/ijrm.v21i1.12666
pmc: PMC9982324
doi:
Types de publication
Journal Article
Langues
eng
Pagination
53-60Informations de copyright
Copyright © 2023 Aliani et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
Références
Curr Opin Obstet Gynecol. 2015 Apr;27(2):133-42
pubmed: 25692506
Pediatr Surg Int. 2018 Mar;34(3):353-361
pubmed: 29124402
Fertil Steril. 2012 Jun;97(6):1331-7.e1-4
pubmed: 22480819
Int J Androl. 2012 Jun;35(3):253-64
pubmed: 22372605
Urology. 2013 Mar;81(3):644-8
pubmed: 23452810
Hum Reprod. 2013 Jan;28(1):230-40
pubmed: 23154066
J Urol. 2015 May;193(5 Suppl):1837-42
pubmed: 25813561
Front Pediatr. 2021 Oct 26;9:648414
pubmed: 34765573
Hum Reprod. 2021 Jan 1;36(1):116-129
pubmed: 33251542
Birth Defects Res. 2017 Aug 15;109(14):1144-1153
pubmed: 28635008
Hum Reprod Update. 2013 Jul-Aug;19(4):330-53
pubmed: 23449641
Arch Gynecol Obstet. 2018 May;297(5):1115-1130
pubmed: 29497821
J Urol. 2013 Apr;189(4):1524-9
pubmed: 23201374
JAMA Pediatr. 2016 Jun 6;170(6):e154934
pubmed: 27043648
Birth Defects Res A Clin Mol Teratol. 2013 Nov;97(11):744-9
pubmed: 23436719
Arch Iran Med. 2012 Apr;15(4):228-31
pubmed: 22424041
Orphanet J Rare Dis. 2014 Feb 20;9:27
pubmed: 24555734
Am J Epidemiol. 2016 Jun 1;183(11):977-87
pubmed: 27188944
Ultrasound Obstet Gynecol. 2018 Jan;51(1):33-42
pubmed: 29164811
Arch Gynecol Obstet. 2015 Oct;292(4):777-98
pubmed: 25877221
Hum Reprod. 2009 Feb;24(2):360-6
pubmed: 19010807
J Pediatr Urol. 2021 Feb;17(1):9-20
pubmed: 33223458