New perspective for an old drug: Can naloxone be considered an antioxidant agent?
Hydrogen peroxide
Naloxone
Oxidative stress
PC12cells
Platinum-based sensors
Journal
Biochemistry and biophysics reports
ISSN: 2405-5808
Titre abrégé: Biochem Biophys Rep
Pays: Netherlands
ID NLM: 101660999
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
02
12
2022
revised:
30
01
2023
accepted:
13
02
2023
entrez:
6
3
2023
pubmed:
7
3
2023
medline:
7
3
2023
Statut:
epublish
Résumé
Experimental evidence indicates that Naloxone (NLX) holds antioxidant properties. The present study aims at verifying the hypothesis that NLX could prevent oxidative stress induced by hydrogen peroxide (H To investigate the antioxidant effect of NLX, initially, we performed electrochemical experiments by means of platinum-based sensors in a cell-free system. Subsequently, NLX was tested in PC12 cells on H This study reveals that NLX counteracts intracellular ROS production, reduces H Overall, these findings provide a starting point for studying further the protective effects of NLX on oxidative stress.
Sections du résumé
Background
UNASSIGNED
Experimental evidence indicates that Naloxone (NLX) holds antioxidant properties. The present study aims at verifying the hypothesis that NLX could prevent oxidative stress induced by hydrogen peroxide (H
Methods
UNASSIGNED
To investigate the antioxidant effect of NLX, initially, we performed electrochemical experiments by means of platinum-based sensors in a cell-free system. Subsequently, NLX was tested in PC12 cells on H
Results
UNASSIGNED
This study reveals that NLX counteracts intracellular ROS production, reduces H
Conclusion
UNASSIGNED
Overall, these findings provide a starting point for studying further the protective effects of NLX on oxidative stress.
Identifiants
pubmed: 36875795
doi: 10.1016/j.bbrep.2023.101441
pii: S2405-5808(23)00022-5
pmc: PMC9975616
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101441Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors have no conflict(s) of interest to declare.
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