Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances: Another link between innate immunity and coagulation.
Acute-phase reaction
ITIH4 protein, human
disseminated intravascular coagulation
multiple organ failure
prognosis
sepsis
Journal
Research and practice in thrombosis and haemostasis
ISSN: 2475-0379
Titre abrégé: Res Pract Thromb Haemost
Pays: United States
ID NLM: 101703775
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
11
09
2022
revised:
15
12
2022
accepted:
08
01
2023
entrez:
6
3
2023
pubmed:
7
3
2023
medline:
7
3
2023
Statut:
epublish
Résumé
The protease inhibitor inter-α-inhibitor heavy chain H4 (ITIH4) has been described as an acute-phase reactant and could potentially aid in sepsis monitoring and prognostication. To investigate ITIH4 plasma levels in sepsis patients compared with healthy controls and to examine the association between ITIH4 and acute-phase response markers, blood coagulation, and organ dysfunction in sepsis. We performed a post hoc study to a prospective cohort study. Patients with septic shock (n = 39) were enrolled upon intensive care unit admission. ITIH4 was analyzed using an in-house immunoassay. Standard coagulation parameters, thrombin generation, fibrin formation and lysis, C-reactive protein, organ dysfunction markers, Sequential Organ Failure Assessment score, and disseminated intravascular coagulation (DIC) score were registered. ITIH4 levels were also investigated in a murine ITIH4 did not display acute-phase behavior as mean ITIH4 levels were not increased in patients with septic shock or in ITIH4 is associated with sepsis-related coagulopathy but is not an acute-phase reactant during septic shock.
Sections du résumé
Background
UNASSIGNED
The protease inhibitor inter-α-inhibitor heavy chain H4 (ITIH4) has been described as an acute-phase reactant and could potentially aid in sepsis monitoring and prognostication.
Objectives
UNASSIGNED
To investigate ITIH4 plasma levels in sepsis patients compared with healthy controls and to examine the association between ITIH4 and acute-phase response markers, blood coagulation, and organ dysfunction in sepsis.
Methods
UNASSIGNED
We performed a post hoc study to a prospective cohort study. Patients with septic shock (n = 39) were enrolled upon intensive care unit admission. ITIH4 was analyzed using an in-house immunoassay. Standard coagulation parameters, thrombin generation, fibrin formation and lysis, C-reactive protein, organ dysfunction markers, Sequential Organ Failure Assessment score, and disseminated intravascular coagulation (DIC) score were registered. ITIH4 levels were also investigated in a murine
Results
UNASSIGNED
ITIH4 did not display acute-phase behavior as mean ITIH4 levels were not increased in patients with septic shock or in
Conclusion
UNASSIGNED
ITIH4 is associated with sepsis-related coagulopathy but is not an acute-phase reactant during septic shock.
Identifiants
pubmed: 36876284
doi: 10.1016/j.rpth.2023.100078
pii: S2475-0379(23)00045-6
pmc: PMC9974438
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100078Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2023 The Authors.
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