New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
23 03 2023
23 03 2023
Historique:
pubmed:
7
3
2023
medline:
25
3
2023
entrez:
6
3
2023
Statut:
ppublish
Résumé
A new series of dual low nanomolar benzothiazole inhibitors of bacterial DNA gyrase and topoisomerase IV were developed. The resulting compounds show excellent broad-spectrum antibacterial activities against Gram-positive
Identifiants
pubmed: 36877255
doi: 10.1021/acs.jmedchem.2c01905
pmc: PMC10041525
doi:
Substances chimiques
Anti-Bacterial Agents
0
DNA Gyrase
EC 5.99.1.3
DNA Topoisomerase IV
EC 5.99.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3968-3994Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J014524/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 110072/Z/15/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P012523/1
Pays : United Kingdom
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