β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview.
Antibiotic
ESKAPE
PBP
Peptidoglycan
Resistance
β-Lactam
Journal
Infectious diseases and therapy
ISSN: 2193-8229
Titre abrégé: Infect Dis Ther
Pays: New Zealand
ID NLM: 101634499
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
21
12
2022
accepted:
30
01
2023
pubmed:
7
3
2023
medline:
7
3
2023
entrez:
6
3
2023
Statut:
ppublish
Résumé
Bacteria acquire β-lactam resistance through a multitude of mechanisms among which production of β-lactamases (enzymes that hydrolyze β-lactams) is the most common, especially in Gram-negatives. Structural changes in the high-molecular-weight, essential penicillin-binding proteins (PBPs) are widespread in Gram-positives and increasingly reported in Gram-negatives. PBP-mediated resistance is largely achieved by accumulation of mutation(s) resulting in reduced binding affinities of β-lactams. Herein, we discuss PBP-mediated resistance among ESKAPE pathogens that cause diverse hospital- and community-acquired infections globally.
Identifiants
pubmed: 36877435
doi: 10.1007/s40121-023-00771-8
pii: 10.1007/s40121-023-00771-8
pmc: PMC10017896
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
829-841Informations de copyright
© 2023. The Author(s).
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