Liver transplantation in metastatic colorectal cancer: are we ready for it?
Journal
British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
01
09
2022
accepted:
17
02
2023
revised:
10
02
2023
medline:
1
5
2023
pubmed:
7
3
2023
entrez:
6
3
2023
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is a prevalent disease worldwide, with more than 50% of patients developing metastases to the liver. Five-year overall survival remains modest among patients with metastatic CRC (mCRC) treated with conventional therapies however, liver transplantation in a highly selected population can improve clinical outcomes with an impressive 5-year overall survival of 83%. Despite liver transplantation appearing to be a promising therapeutical option for well-selected patients with mCRC with the liver-limited disease, these data come from small monocentric trials which included a heterogeneous population. Currently, several clinical trials are evaluating liver transplantation in this scenario, aiming for a more accurate patient selection by integrating liquid biopsy, tissue profiling, and nuclear medicine to the already known clinical biomarkers that eventually may lead to a survival improvement. In this paper, the clinical outcomes and inclusion criteria from the most relevant clinical trials and clinical series involving liver transplantation in patients with liver-limited disease colorectal cancer are reviewed as well as the trials currently recruiting.
Identifiants
pubmed: 36879000
doi: 10.1038/s41416-023-02213-1
pii: 10.1038/s41416-023-02213-1
pmc: PMC10147684
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1797-1806Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
Références
BJS Open. 2020 Jun;4(3):467-477
pubmed: 32333527
BJS Open. 2018 Oct 25;3(2):180-185
pubmed: 30957065
JAMA Oncol. 2019 Aug 01;5(8):1124-1131
pubmed: 31070691
N Engl J Med. 2019 Oct 24;381(17):1632-1643
pubmed: 31566309
Transpl Int. 2022 May 30;35:10404
pubmed: 35707633
Ann Surg Oncol. 2015 Aug;22(8):2761-71
pubmed: 25572686
Mol Oncol. 2019 Sep;13(9):1827-1835
pubmed: 31322322
Ann Surg. 2023 Aug 1;278(2):239-245
pubmed: 36082986
Ann Oncol. 2016 Aug;27(8):1386-422
pubmed: 27380959
Int J Surg. 2020 Oct;82S:87-92
pubmed: 32305529
Ther Adv Med Oncol. 2021 Feb 22;13:1758835921992974
pubmed: 33747149
Eur J Cancer. 2017 Jan;70:87-98
pubmed: 27907852
JAMA Oncol. 2017 Feb 01;3(2):211-219
pubmed: 27787550
Ann N Y Acad Sci. 1994 Sep 15;733:507-14
pubmed: 7978901
Cancer Treat Rev. 2015 Nov;41(9):729-41
pubmed: 26417845
Lancet Oncol. 2013 Nov;14(12):1208-15
pubmed: 24120480
Transplant Proc. 1991 Feb;23(1 Pt 2):1567-8
pubmed: 1989293
J Natl Cancer Inst. 2011 Jan 5;103(1):21-30
pubmed: 21123833
Ann Oncol. 2017 Aug 01;28(8):1713-1729
pubmed: 28407110
Lancet. 2019 Oct 19;394(10207):1467-1480
pubmed: 31631858
Nat Rev Clin Oncol. 2020 Jan;17(1):11-32
pubmed: 31289352
Transpl Int. 2021 Nov;34(11):2004-2005
pubmed: 34490945
N Engl J Med. 2020 Dec 3;383(23):2207-2218
pubmed: 33264544
Transpl Int. 2021 Nov;34(11):2205-2213
pubmed: 34792825
World J Hepatol. 2015 Oct 8;7(22):2396-403
pubmed: 26464755
Exp Clin Transplant. 2022 Feb;20(2):113-121
pubmed: 35282808
Sci Transl Med. 2016 Jul 6;8(346):346ra92
pubmed: 27384348
Lancet. 2013 Jan 26;381(9863):303-12
pubmed: 23177514
Ann Surg. 2013 May;257(5):800-6
pubmed: 23360920
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Surgery. 2012 Jun;151(6):860-70
pubmed: 22316439
JAMA Oncol. 2019 Dec 1;5(12):1710-1717
pubmed: 31621801
Eur J Nucl Med Mol Imaging. 2018 Feb;45(2):218-225
pubmed: 29026950
Ann Surg Oncol. 2014 Apr;21(4):1323-9
pubmed: 24370906
Ann Surg. 2020 May;271(5):e122-e124
pubmed: 32310616
Lancet Gastroenterol Hepatol. 2021 Nov;6(11):933-946
pubmed: 34506756
JAMA Surg. 2022 Jun 1;157(6):524-530
pubmed: 35353121
Ann Surg. 1999 Sep;230(3):309-18; discussion 318-21
pubmed: 10493478
Br J Cancer. 2010 Apr 27;102(9):1313-8
pubmed: 20424612
Clin Nucl Med. 2015 May;40(5):e259-64
pubmed: 25742225
JCO Precis Oncol. 2022 Nov;6:e2200244
pubmed: 36356286
Cancer Commun (Lond). 2020 Sep;40(9):461-464
pubmed: 32762027
Nucl Med Commun. 2020 Sep;41(9):916-923
pubmed: 32796480
Ann Surg. 2019 Aug;270(2):327-332
pubmed: 29916882
Liver Transpl. 2017 Aug;23(8):1073-1076
pubmed: 28544246
J Surg Oncol. 2017 Sep;116(3):288-297
pubmed: 28513862
World J Hepatol. 2016 Jul 28;8(21):874-80
pubmed: 27478537
Ann Surg. 2004 Sep;240(3):438-47; discussion 447-50
pubmed: 15319715
BMC Cancer. 2010 May 11;10:190
pubmed: 20459775
Transpl Int. 2010 Jul;23(7):679-85
pubmed: 20477993
J Natl Cancer Inst. 2014 Jun 12;106(7):
pubmed: 24925349
J Surg Oncol. 2018 Mar;117(4):634-643
pubmed: 29165816
Transplantation. 2017 Apr;101(4S Suppl 2):S1-S56
pubmed: 28328734
Ann Surg. 2006 Aug;244(2):254-9
pubmed: 16858188
Br J Surg. 2018 Feb;105(3):295-301
pubmed: 29168565
Front Surg. 2021 Jul 20;8:693387
pubmed: 34355016
Lancet Oncol. 2022 Oct;23(10):1332-1342
pubmed: 36058227
Ann Oncol. 2017 Aug 01;28(8):1862-1868
pubmed: 28449055
Ann Oncol. 2019 Jul 1;30(7):1173-1177
pubmed: 30977776
Ann Surg. 2020 Feb;271(2):212-218
pubmed: 31188200
Nat Rev Dis Primers. 2021 Jan 21;7(1):6
pubmed: 33479224
JAMA Oncol. 2017 Feb 01;3(2):194-201
pubmed: 27722750
Ann Gastroenterol Surg. 2019 Jan 14;3(1):50-56
pubmed: 30697610
Int J Colorectal Dis. 2011 Aug;26(8):967-81
pubmed: 21584664
Transpl Int. 2019 Nov;32(11):1144-1150
pubmed: 31209941
N Engl J Med. 2015 May 14;372(20):1909-19
pubmed: 25970050