Transient Parvovirus B19 DNAemia After Kidney Transplantation: A 2-Sided Story.

DNAemia kidney transplantation parvovirus B19 viral activity viremia

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Mar 2023
Historique:
received: 17 11 2022
accepted: 07 02 2023
entrez: 7 3 2023
pubmed: 8 3 2023
medline: 8 3 2023
Statut: epublish

Résumé

Parvovirus B19 (B19V) DNAemia appears to be a relatively common finding after kidney transplantation. However, not all DNAemia signifies active infection with replicating virus. This study screened 134 patients posttransplantation for B19V DNAemia and identified 2 cases in which viral DNA was present after transplantation, with the donor kidney as probable source of the DNA. In both cases intact viral particles could not be detected using an endonuclease method, indicating the presence of noninfectious DNA remnants.

Identifiants

pubmed: 36879626
doi: 10.1093/ofid/ofad079
pii: ofad079
pmc: PMC9984985
doi:

Types de publication

Journal Article

Langues

eng

Pagination

ofad079

Informations de copyright

© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Déclaration de conflit d'intérêts

Potential conflicts of interest. All authors: No reported conflicts.

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Auteurs

Anne Russcher (A)

Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

Marijke Molenaar-de Backer (M)

Donor Medicine Research, Department of Blood-borne Infections, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.

Caroline de Brouwer (C)

Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

Kyra Dijkstra (K)

Department of Pathology and Leiden Transplant Center, Leiden University Medical Center, Leiden, The Netherlands.

Jesper Kers (J)

Department of Pathology and Leiden Transplant Center, Leiden University Medical Center, Leiden, The Netherlands.

Aiko de Vries (A)

Department of Nephrology and Leiden Transplant Center, Leiden University Medical Center, Leiden, The Netherlands.

Hans Zaaijer (H)

Donor Medicine Research, Department of Blood-borne Infections, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands.

Ann Vossen (A)

Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

Aloysius Kroes (A)

Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

Classifications MeSH