ICI efficacy information portal: a knowledgebase for responder prediction to immune checkpoint inhibitors.
Journal
NAR cancer
ISSN: 2632-8674
Titre abrégé: NAR Cancer
Pays: England
ID NLM: 101769553
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
01
10
2022
revised:
20
12
2022
accepted:
11
02
2023
entrez:
7
3
2023
pubmed:
8
3
2023
medline:
8
3
2023
Statut:
epublish
Résumé
Immune checkpoint inhibitors (ICIs) have led to durable responses in cancer patients, yet their efficacy varies significantly across cancer types and patients. To stratify patients based on their potential clinical benefits, there have been substantial research efforts in identifying biomarkers and computational models that can predict the efficacy of ICIs, and it has become difficult to keep track of all of them. It is also difficult to compare findings of different studies since they involve different cancer types, ICIs, and various other details. To make it easy to access the latest information about ICI efficacy, we have developed a knowledgebase and a corresponding web-based portal (https://iciefficacy.org/). Our knowledgebase systematically records information about latest publications related to ICI efficacy, predictors proposed, and datasets used to test them. All information recorded is checked carefully by a manual curation process. The web-based portal provides functions to browse, search, filter, and sort the information. Digests of method details are provided based on the original descriptions in the publications. Evaluation results of the effectiveness of the predictors reported in the publications are summarized for quick overviews. Overall, our resource provides centralized access to the burst of information produced by the vibrant research on ICI efficacy.
Identifiants
pubmed: 36879684
doi: 10.1093/narcan/zcad012
pii: zcad012
pmc: PMC9984987
doi:
Types de publication
Journal Article
Langues
eng
Pagination
zcad012Subventions
Organisme : NCI NIH HHS
ID : P30 CA030199
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG075483
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of NAR Cancer.
Références
Cell. 2021 Feb 4;184(3):596-614.e14
pubmed: 33508232
Nat Immunol. 2019 Nov;20(11):1425-1434
pubmed: 31611702
J Genet Genomics. 2021 May 20;48(5):361-368
pubmed: 34127402
AJNR Am J Neuroradiol. 2022 May;43(5):675-681
pubmed: 35483906
Biomolecules. 2020 Jul 16;10(7):
pubmed: 32708698
Mol Cancer. 2019 Nov 6;18(1):155
pubmed: 31690319
Cell Rep. 2019 Dec 10;29(11):3367-3373.e4
pubmed: 31825821
Patterns (N Y). 2021 Jun 30;2(8):100293
pubmed: 34430923
Science. 2018 Mar 23;359(6382):1350-1355
pubmed: 29567705
Nat Rev Cancer. 2019 Mar;19(3):133-150
pubmed: 30755690
Cell. 2017 Feb 9;168(4):707-723
pubmed: 28187290
Nature. 2018 Feb 22;554(7693):544-548
pubmed: 29443960
Nat Med. 2019 Dec;25(12):1836-1838
pubmed: 31806908
Nat Biotechnol. 2022 Jul;40(7):981
pubmed: 35790882
Eur J Cancer. 2009 Jan;45(2):228-47
pubmed: 19097774
Nat Biotechnol. 2022 Apr;40(4):499-506
pubmed: 34725502
Nat Med. 2022 Aug;28(8):1599-1611
pubmed: 35739268
Science. 2015 Apr 3;348(6230):124-8
pubmed: 25765070
Science. 2015 Oct 9;350(6257):207-211
pubmed: 26359337
Lancet. 2021 Mar 13;397(10278):1010-1022
pubmed: 33285141
Nucleic Acids Res. 2002 Jan 1;30(1):207-10
pubmed: 11752295
F1000Res. 2020 Aug 24;9:1028
pubmed: 33214875
Cell. 2021 Oct 14;184(21):5309-5337
pubmed: 34624224
Nat Med. 2018 Oct;24(10):1550-1558
pubmed: 30127393
Genomics Proteomics Bioinformatics. 2021 Feb;19(1):1-12
pubmed: 33662628
Nature. 2018 Aug;560(7718):382-386
pubmed: 30089911
Nat Med. 2019 Dec;25(12):1833-1835
pubmed: 31806907
Nature. 2014 Nov 27;515(7528):568-71
pubmed: 25428505
Cancer Discov. 2018 Sep;8(9):1069-1086
pubmed: 30115704
Cell. 2015 Apr 9;161(2):205-14
pubmed: 25860605
Sci Rep. 2017 Aug 31;7(1):10117
pubmed: 28860628
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
JCI Insight. 2018 Aug 23;3(16):
pubmed: 30135306
Nucleic Acids Res. 2020 Jan 8;48(D1):D132-D141
pubmed: 31598695
Phys Med Biol. 2015 Jul 21;60(14):5471-96
pubmed: 26119045
N Engl J Med. 2017 Dec 21;377(25):2500-2501
pubmed: 29262275
Cell Rep. 2017 Jan 3;18(1):248-262
pubmed: 28052254
Immunity. 2016 May 17;44(5):989-1004
pubmed: 27192565
Nat Genet. 2013 Oct;45(10):1113-20
pubmed: 24071849
Annu Rev Pathol. 2021 Jan 24;16:223-249
pubmed: 33197221
Genomics Proteomics Bioinformatics. 2022 Aug 29;:
pubmed: 36049666
J Immunother Cancer. 2020 Oct;8(2):
pubmed: 33109630
N Engl J Med. 2015 Jan 22;372(4):311-9
pubmed: 25482239
Nucleic Acids Res. 2014 Jan;42(Database issue):D975-9
pubmed: 24297256
Nat Med. 2018 Oct;24(10):1545-1549
pubmed: 30127394