Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during postnatal growth.
Developmental biology
Systems biology
Transcriptomics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Mar 2023
17 Mar 2023
Historique:
received:
06
07
2022
revised:
20
12
2022
accepted:
25
01
2023
entrez:
7
3
2023
pubmed:
8
3
2023
medline:
8
3
2023
Statut:
epublish
Résumé
At birth, the lung is still immature, heightening susceptibility to injury but enhancing regenerative capacity. Angiogenesis drives postnatal lung development. Therefore, we profiled the transcriptional ontogeny and sensitivity to injury of pulmonary endothelial cells (EC) during early postnatal life. Although subtype speciation was evident at birth, immature lung EC exhibited transcriptomes distinct from mature counterparts, which progressed dynamically over time. Gradual, temporal changes in aerocyte capillary EC (CAP2) contrasted with more marked alterations in general capillary EC (CAP1) phenotype, including distinct CAP1 present only in the early alveolar lung expressing
Identifiants
pubmed: 36879800
doi: 10.1016/j.isci.2023.106097
pii: S2589-0042(23)00174-8
pmc: PMC9984561
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106097Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL154002
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155828
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL148861
Pays : United States
Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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