Vitamin D Receptor Polymorphisms Among the Turkish Population are Associated with Multiple Sclerosis.
Multiple Sclerosis
Polymorphism
VitD Receptor
Journal
Balkan journal of medical genetics : BJMG
ISSN: 1311-0160
Titre abrégé: Balkan J Med Genet
Pays: Poland
ID NLM: 9806959
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
entrez:
7
3
2023
pubmed:
8
3
2023
medline:
8
3
2023
Statut:
epublish
Résumé
Multiple sclerosis (MS) is an inflammatory disease characterized by demyelination and axonal degeneration affecting the central nervous system. Among the genetic factors suggested to be associated with this disease are polymorphisms to the vitamin D receptor (VDR) gene. We tested the hypothesis that polymorphisms in the vitamin D receptor (VDR) gene are associated with MS. The aim of the study was to investigate the relationship of MS with the VDR gene Fok-I, Bsm-I and Taq-I polymorphisms among the Turkish population. This study contains 271 MS patients and 203 healthy controls. Genomic DNA was isolated from the samples and the VDR gene Fok-I, Bsm-I and Taq-I polymorphism regions were amplified by polymerase chain reaction (PCR). The PCR products were digested, and the genotypes were determined based on size of digested PCR products. Our results demonstrate associations between MS and the distribution of the VDR gene Fok-I T/T polymorphism genotype in a dominant model, VDR gene Fok-I T allele frequency, distribution of VDR gene Taq-I C/C polymorphism genotype in a dominant model and VDR gene Taq-I C allele frequency (Pearson test, p<0.05). However, there was no association between MS and the VDR gene Bsm-I polymorphisms for the genotype distribution (Pearson test, p>0.05) or allele frequency (Pearson test, p>0.05). Fok-I and Taq-I VDR gene polymorphisms are significantly associated with MS in dominant, homozygote and heterozygote inheritance models among the Turkish population.
Identifiants
pubmed: 36880035
doi: 10.2478/bjmg-2022-0003
pii: bjmg-2022-0003
pmc: PMC9985364
doi:
Types de publication
Journal Article
Langues
eng
Pagination
41-50Informations de copyright
© 2022 Bulan B, Hoscan AY, Keskin SN, Cavus A, Culcu EA, Isik N, List EO, Arman A, published by Sciendo.
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