Construction of oxygenated 2-azabicyclo[2.2.1]heptanes

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
21 Mar 2023
Historique:
pubmed: 8 3 2023
medline: 8 3 2023
entrez: 7 3 2023
Statut: epublish

Résumé

Herein, we describe a palladium-catalyzed 1,2-aminoacyloxylation of cyclopentenes to synthesize oxygenated 2-azabicyclo[2.2.1]heptanes. This reaction proceeds efficiently with a broad array of substrates. The products could be further functionalized to build up a library of bridged aza-bicyclic structures.

Identifiants

DOI: 10.1039/d2cc06581a PMID: 36880405
pubmed: 36880405
doi: 10.1039/d2cc06581a
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3574-3577

Auteurs

Haipin Zhou (H)

College of Materials & Chemical Engineering, Chuzhou University, 1 West Huifeng Road, Chuzhou, 239000, P. R. China.
State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China. ajlin@cpu.edu.cn.

Rui Pan (R)

State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China. ajlin@cpu.edu.cn.

Menghua Xu (M)

State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China. ajlin@cpu.edu.cn.

Jiao Ma (J)

State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China. ajlin@cpu.edu.cn.

Aijun Lin (A)

State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China. ajlin@cpu.edu.cn.
ORCID: 0000-0001-5786-4537

Hequan Yao (H)

State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, P. R. China. ajlin@cpu.edu.cn.
ORCID: 0000-0003-4865-820X

Classifications MeSH