Hydrogel mechanics regulate fibroblast DNA methylation and chromatin condensation.
Journal
Biomaterials science
ISSN: 2047-4849
Titre abrégé: Biomater Sci
Pays: England
ID NLM: 101593571
Informations de publication
Date de publication:
11 Apr 2023
11 Apr 2023
Historique:
medline:
13
4
2023
pubmed:
8
3
2023
entrez:
7
3
2023
Statut:
epublish
Résumé
Cellular mechanotransduction plays a central role in fibroblast activation during fibrotic disease progression, leading to increased tissue stiffness and reduced organ function. While the role of epigenetics in disease mechanotransduction has begun to be appreciated, little is known about how substrate mechanics, particularly the timing of mechanical inputs, regulate epigenetic changes such as DNA methylation and chromatin reorganization during fibroblast activation. In this work, we engineered a hyaluronic acid hydrogel platform with independently tunable stiffness and viscoelasticity to model normal (storage modulus,
Identifiants
pubmed: 36880435
doi: 10.1039/d2bm02058k
pmc: PMC10329270
mid: NIHMS1909038
doi:
Substances chimiques
Hydrogels
0
Chromatin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2886-2897Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM138187
Pays : United States
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