DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.
DNA demethylation
FoxP3
IL-2
Tet enzymes
Treg development
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
04 05 2023
04 05 2023
Historique:
revised:
10
02
2023
received:
06
06
2022
accepted:
16
02
2023
medline:
5
5
2023
pubmed:
8
3
2023
entrez:
7
3
2023
Statut:
ppublish
Résumé
Regulatory T (T reg) cells developing in the thymus are essential to maintain tolerance and prevent fatal autoimmunity in mice and humans. Expression of the T reg lineage-defining transcription factor FoxP3 is critically dependent upon T cell receptor (TCR) and interleukin-2 (IL-2) signaling. Here, we report that ten-eleven translocation (Tet) enzymes, which are DNA demethylases, are required early during double-positive (DP) thymic T cell differentiation and prior to the upregulation of FoxP3 in CD4 single-positive (SP) thymocytes, to promote Treg differentiation. We show that Tet3 selectively controls the development of CD25
Identifiants
pubmed: 36880575
doi: 10.15252/embr.202255543
pmc: PMC10157375
doi:
Substances chimiques
Interleukin-2
0
Receptors, Antigen, T-Cell
0
Forkhead Transcription Factors
0
Banques de données
GEO
['GSE221847']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e55543Subventions
Organisme : NIDDK NIH HHS
ID : RC2 DK124207
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007485
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL152960
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL091842
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL163024
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007511
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL163556
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL140261
Pays : United States
Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
Références
Nature. 2010 Feb 11;463(7282):808-12
pubmed: 20072126
PLoS Biol. 2007 Feb;5(2):e38
pubmed: 17298177
Cell. 2008 May 30;133(5):775-87
pubmed: 18510923
Nat Rev Immunol. 2016 Apr;16(4):220-33
pubmed: 27026074
J Immunol. 2007 Apr 1;178(7):4022-6
pubmed: 17371955
Nat Immunol. 2017 Jan;18(1):45-53
pubmed: 27869820
Immunity. 2008 Apr;28(4):546-58
pubmed: 18387831
Nat Immunol. 2005 Apr;6(4):331-7
pubmed: 15785758
Cell. 2006 Jul 28;126(2):375-87
pubmed: 16873067
Annu Rev Immunol. 2012;30:531-64
pubmed: 22224781
Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10772-6
pubmed: 7479881
J Exp Med. 2016 Mar 7;213(3):377-97
pubmed: 26903244
J Immunol. 2004 May 1;172(9):5149-53
pubmed: 15100250
Nat Commun. 2019 May 1;10(1):2011
pubmed: 31043609
BMC Gastroenterol. 2012 Jul 31;12:97
pubmed: 22849659
Annu Rev Immunol. 2020 Apr 26;38:541-566
pubmed: 32017635
Immunity. 2015 Aug 18;43(2):251-63
pubmed: 26275994
Nat Commun. 2018 Sep 5;9(1):3594
pubmed: 30185805
EMBO Rep. 2023 May 4;24(5):e55543
pubmed: 36880575
Eur J Immunol. 2008 Jun;38(6):1654-63
pubmed: 18493985
J Exp Med. 2011 Jun 6;208(6):1279-89
pubmed: 21606508
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Immunity. 2009 Jan 16;30(1):92-107
pubmed: 19119024
Autoimmun Rev. 2011 Oct;10(12):744-55
pubmed: 21621000
J Immunol. 2007 Feb 15;178(4):2018-27
pubmed: 17277105
Science. 2004 Jul 9;305(5681):248-51
pubmed: 15247480
Immunity. 2012 Nov 16;37(5):785-99
pubmed: 23123060
Nat Commun. 2022 Mar 18;13(1):1477
pubmed: 35304452
J Immunol. 2007 Jan 1;178(1):280-90
pubmed: 17182565
J Immunol. 2018 Jun 15;200(12):3926-3933
pubmed: 29728511
Nat Immunol. 2017 Feb;18(2):173-183
pubmed: 27992401
Nat Immunol. 2015 Jul;16(7):746-54
pubmed: 26030024
Cell Rep. 2018 Oct 30;25(5):1204-1213.e4
pubmed: 30380412
Cancer Cell. 2011 Jul 12;20(1):11-24
pubmed: 21723200
Nat Methods. 2013 Dec;10(12):1213-8
pubmed: 24097267
J Immunol. 2004 Apr 1;172(7):4275-84
pubmed: 15034041
Bio Protoc. 2019 Aug 20;9(16):e3335
pubmed: 33654840
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3306-15
pubmed: 25071199
J Exp Med. 2019 Nov 4;216(11):2466-2478
pubmed: 31434685
J Immunol. 2003 Apr 15;170(8):3939-43
pubmed: 12682220
J Immunol. 2013 Apr 1;190(7):3180-8
pubmed: 23420886
J Immunol. 2014 Dec 1;193(11):5525-33
pubmed: 25348623
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):612-7
pubmed: 23267098
Int J Clin Exp Pathol. 2014 Jul 15;7(8):4557-76
pubmed: 25197329
Nat Immunol. 2015 Jun;16(6):628-34
pubmed: 25939024
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7061-6
pubmed: 26038559
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5138-43
pubmed: 15790681
Nat Immunol. 2003 Mar;4(3):235-40
pubmed: 12548284
Nat Immunol. 2016 Nov;17(11):1322-1333
pubmed: 27595233
Mucosal Immunol. 2015 Nov;8(6):1297-312
pubmed: 25807185
Front Immunol. 2019 Feb 12;10:210
pubmed: 30809228
Nat Rev Genet. 2017 Sep;18(9):517-534
pubmed: 28555658
Nat Immunol. 2005 Nov;6(11):1142-51
pubmed: 16227984
Blood. 2007 May 15;109(10):4368-75
pubmed: 17227828
Front Immunol. 2012 May 10;3:102
pubmed: 22590468
Cell Stem Cell. 2014 Oct 2;15(4):459-471
pubmed: 25280220
Lab Invest. 2018 Jul;98(7):844-855
pubmed: 29849125
Nat Immunol. 2017 Sep;18(9):1035-1045
pubmed: 28759003
Eur J Immunol. 2021 Mar;51(3):580-593
pubmed: 32730634