Hemolytic-Uremic Syndrome in Children.

Cattle Animals Humans Child Hemolytic-Uremic Syndrome / diagnosis Kidney Failure, Chronic Thrombocytopenia
Alternative pathway of complement Eculizumab Hemolytic uremic syndrome Shiga toxin Thrombotic microangiopathy

Journal

Pediatric clinics of North America
ISSN: 1557-8240
Titre abrégé: Pediatr Clin North Am
Pays: United States
ID NLM: 0401126

Informations de publication

Date de publication:
12 2022
Historique:
entrez: 7 3 2023
pubmed: 8 3 2023
medline: 10 3 2023
Statut: ppublish

Résumé

Hemolytic uremic syndrome is characterized by a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney failure. Most cases are caused by Shiga-toxin-producing bacteria, especially Escherichia coli. Transmission occurs through ground beef and unpasteurized milk. STEC-HUS is the main cause of acute renal failure in children. Management remains supportive. Immediate outcome is most often. Atypical HUS represents about 5% of cases, has a relapsing course with more than half of the patients progressing to end-stage kidney failure. Most cases are due to variants in complement regulators of the alternative pathway. Complement inhibitors, such as eculizumab, have considerably improved the prognosis.

Identifiants

DOI: 10.1016/j.pcl.2022.07.006 PMID: 36880929
pubmed: 36880929
pii: S0031-3955(22)00093-1
doi: 10.1016/j.pcl.2022.07.006
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1181-1197

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Olivia Boyer (O)

Pediatric Nephrology, Necker Enfants Malades Hospital, Université Paris Cité, France; Néphrologie Pédiatrique, Hôpital Necker, 149 Rue de Sèvres, Paris 75015, France.

Patrick Niaudet (P)

Pediatric Nephrology, Necker Enfants Malades Hospital, Université Paris Cité, France. Electronic address: pniaudet@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Hemolytic-Uremic Syndrome in Children.
questionsmedicales.fr › Eucaryotes › Animaux › Hemolytic-Uremic Syndrome in Children.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hemolytic-Uremic Syndrome in Children.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Hemolytic-Uremic Syndrome in Children.
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Anomalies des plaquettes › Thrombopénie › Microangiopathies thrombotiques › Syndrome hémolytique et urémique › Hemolytic-Uremic Syndrome in Children.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Défaillance rénale chronique › Hemolytic-Uremic Syndrome in Children.
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Anomalies des plaquettes › Thrombopénie › Hemolytic-Uremic Syndrome in Children.