A 16-month longitudinal investigation of risk and protective factors for mental health outcomes throughout three national lockdowns and a mass vaccination campaign: Evidence from a weighted Israeli sample during COVID-19.


Journal

Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385

Informations de publication

Date de publication:
05 2023
Historique:
received: 06 08 2022
revised: 13 02 2023
accepted: 18 02 2023
medline: 18 4 2023
pubmed: 8 3 2023
entrez: 7 3 2023
Statut: ppublish

Résumé

COVID-19 is an ongoing global crisis, with a multitude of factors that affect mental health worldwide. We explored potential predictors for the emergence and maintenance of depression, anxiety, and posttraumatic stress symptoms (PTSS) in the general population in Israel. Across the span of 16 months, 2478 people completed a repeated self-report survey which inquired psychiatric symptoms and pandemic related stress factors (PRSF). We applied mixed-effects models to assess how each stressor contributes to depression, anxiety and PTSS at each time point, and longitudinally assessed participants who completed at least two consecutive surveys (n = 400). We weighted our sample to increase representativeness of the population. Fatigue was the strongest predictor for depression, anxiety and PTSS at all time points, and predicted deterioration overtime. Financial concerns associated with depression and anxiety at all time points, and with their deterioration overtime. Health related concerns were uniquely associated with anxiety and PTSS at all time points and their deterioration, but not with depression. Improvement in sense of protection overtime associated with decrease in depression and anxiety. Hesitancy towards vaccination was associated to higher financial concerns and lower sense of protection by the authorities. Our findings accentuate the multitude of risk factors for psychiatric morbidity during COVID-19, and the centrality of fatigue in determining mental health outcomes.

Sections du résumé

BACKGROUND
COVID-19 is an ongoing global crisis, with a multitude of factors that affect mental health worldwide. We explored potential predictors for the emergence and maintenance of depression, anxiety, and posttraumatic stress symptoms (PTSS) in the general population in Israel.
METHODS
Across the span of 16 months, 2478 people completed a repeated self-report survey which inquired psychiatric symptoms and pandemic related stress factors (PRSF). We applied mixed-effects models to assess how each stressor contributes to depression, anxiety and PTSS at each time point, and longitudinally assessed participants who completed at least two consecutive surveys (n = 400). We weighted our sample to increase representativeness of the population.
RESULTS
Fatigue was the strongest predictor for depression, anxiety and PTSS at all time points, and predicted deterioration overtime. Financial concerns associated with depression and anxiety at all time points, and with their deterioration overtime. Health related concerns were uniquely associated with anxiety and PTSS at all time points and their deterioration, but not with depression. Improvement in sense of protection overtime associated with decrease in depression and anxiety. Hesitancy towards vaccination was associated to higher financial concerns and lower sense of protection by the authorities.
CONCLUSIONS
Our findings accentuate the multitude of risk factors for psychiatric morbidity during COVID-19, and the centrality of fatigue in determining mental health outcomes.

Identifiants

pubmed: 36881950
pii: S0165-1781(23)00072-0
doi: 10.1016/j.psychres.2023.115119
pmc: PMC9968478
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

115119

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflicts of interest.

Auteurs

Nimrod Hertz-Palmor (N)

The Child and Adolescent Psychiatry Division, Edmond and Lily Safra Children Hospital at Sheba Medical Center, Israel; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK; School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, Israel. Electronic address: nimrod.hertz@mrc-cbu.cam.ac.uk.

Shachar Ruppin (S)

School of Psychological Sciences, Faculty of Social Sciences, Tel Aviv University, Israel.

Noam Matalon (N)

The Child and Adolescent Psychiatry Division, Edmond and Lily Safra Children Hospital at Sheba Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel.

Mariela Mosheva (M)

The Child and Adolescent Psychiatry Division, Edmond and Lily Safra Children Hospital at Sheba Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel.

Shirel Dorman-Ilan (S)

The Child and Adolescent Psychiatry Division, Edmond and Lily Safra Children Hospital at Sheba Medical Center, Israel.

Yaffa Serur (Y)

The Child and Adolescent Psychiatry Division, Edmond and Lily Safra Children Hospital at Sheba Medical Center, Israel.

Asia Avinir (A)

The Child and Adolescent Psychiatry Division, Edmond and Lily Safra Children Hospital at Sheba Medical Center, Israel.

Ehud Mekori-Domachevsky (E)

The Child and Adolescent Psychiatry Division, Edmond and Lily Safra Children Hospital at Sheba Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel.

Ilanit Hasson-Ohayon (I)

The Psychology Department, Bar-Ilan University, Israel.

Raz Gross (R)

The Child and Adolescent Psychiatry Division, Edmond and Lily Safra Children Hospital at Sheba Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel.

Doron Gothelf (D)

The Child and Adolescent Psychiatry Division, Edmond and Lily Safra Children Hospital at Sheba Medical Center, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel; Sagol School of Neuroscience, Tel Aviv University, Israel.

Itai M Pessach (IM)

Sackler Faculty of Medicine, Tel Aviv University, Israel; Pediatric Intensive Care Unit, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.

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