Circulating levels of micronutrients and risk of infections: a Mendelian randomization study.

Humans Micronutrients Copper Mendelian Randomization Analysis Vitamin B 12 Ascorbic Acid
Copper Gastrointestinal infections Infections Mendelian randomization Micronutrients

Journal

BMC medicine
ISSN: 1741-7015
Titre abrégé: BMC Med
Pays: England
ID NLM: 101190723

Informations de publication

Date de publication:
08 03 2023
Historique:
received: 02 09 2022
accepted: 12 02 2023
entrez: 7 3 2023
pubmed: 8 3 2023
medline: 10 3 2023
Statut: epublish

Résumé

Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized controlled trials of micronutrients and infections are limited. We performed Mendelian randomization (MR) analyses to evaluate the effect of blood levels of eight micronutrients (copper, iron, selenium, zinc, beta-carotene, vitamin B12, vitamin C, and vitamin D) on the risk of three infections (gastrointestinal infections, pneumonia, and urinary tract infections). Two-sample MR was conducted using publicly available summary statistics from independent cohorts of European ancestry. For the three infections, we used data from UK Biobank and FinnGen. Inverse variance-weighted MR analyses were performed, together with a range of sensitivity analyses. The threshold for statistical significance was set at P < 2.08E-03. We found a significant association between circulating levels of copper and risk of gastrointestinal infections, where a one standard deviation increase in blood levels of copper was associated with an odds ratio of gastrointestinal infections of 0.91 (95% confidence interval 0.87 to 0.97, P = 1.38E-03). This finding was robust in extensive sensitivity analyses. There was no clear association between the other micronutrients and the risk of infection. Our results strongly support a role of copper in the susceptibility to gastrointestinal infections.

Sections du résumé

BACKGROUND
Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized controlled trials of micronutrients and infections are limited. We performed Mendelian randomization (MR) analyses to evaluate the effect of blood levels of eight micronutrients (copper, iron, selenium, zinc, beta-carotene, vitamin B12, vitamin C, and vitamin D) on the risk of three infections (gastrointestinal infections, pneumonia, and urinary tract infections).
METHODS
Two-sample MR was conducted using publicly available summary statistics from independent cohorts of European ancestry. For the three infections, we used data from UK Biobank and FinnGen. Inverse variance-weighted MR analyses were performed, together with a range of sensitivity analyses. The threshold for statistical significance was set at P < 2.08E-03.
RESULTS
We found a significant association between circulating levels of copper and risk of gastrointestinal infections, where a one standard deviation increase in blood levels of copper was associated with an odds ratio of gastrointestinal infections of 0.91 (95% confidence interval 0.87 to 0.97, P = 1.38E-03). This finding was robust in extensive sensitivity analyses. There was no clear association between the other micronutrients and the risk of infection.
CONCLUSIONS
Our results strongly support a role of copper in the susceptibility to gastrointestinal infections.

Identifiants

DOI: 10.1186/s12916-023-02780-3 PMID: 36882828 PMC: PMC9993583
pubmed: 36882828
doi: 10.1186/s12916-023-02780-3
pii: 10.1186/s12916-023-02780-3
pmc: PMC9993583
doi:

Substances chimiques

Micronutrients 0
Copper 789U1901C5
Vitamin B 12 P6YC3EG204
Ascorbic Acid PQ6CK8PD0R

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

84

Informations de copyright

© 2023. The Author(s).

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Auteurs

Helene M Flatby (HM)

Gemini Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Prinsesse Kristinas gate 3, Akutten og Hjerte-lunge-senteret, 3. etg, 7491, Trondheim, Norway. helene.flatby@ntnu.no.
Clinic of Anaesthesia and Intensive Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. helene.flatby@ntnu.no.
ORCID: 0000-0002-5700-020X

Anuradha Ravi (A)

Gemini Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Prinsesse Kristinas gate 3, Akutten og Hjerte-lunge-senteret, 3. etg, 7491, Trondheim, Norway.
Clinic of Anaesthesia and Intensive Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
ORCID: 0000-0001-5668-0090

Jan K Damås (JK)

Gemini Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Prinsesse Kristinas gate 3, Akutten og Hjerte-lunge-senteret, 3. etg, 7491, Trondheim, Norway.
Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Infectious Diseases, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
ORCID: 0000-0003-4268-671X

Erik Solligård (E)

Gemini Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Prinsesse Kristinas gate 3, Akutten og Hjerte-lunge-senteret, 3. etg, 7491, Trondheim, Norway.
Clinic of Anaesthesia and Intensive Care, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
ORCID: 0000-0001-6173-3580

Tormod Rogne (T)

Gemini Center for Sepsis Research, Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Prinsesse Kristinas gate 3, Akutten og Hjerte-lunge-senteret, 3. etg, 7491, Trondheim, Norway.
Department of Chronic Disease Epidemiology and Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, CT, USA.
ORCID: 0000-0002-9581-7384

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Circulating levels of micronutrients and risk...
questionsmedicales.fr › Aliments et boissons › Aliments › Nutriments › Micronutriments › Circulating levels of micronutrients and risk...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Circulating levels of micronutrients and risk...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Circulating levels of micronutrients and risk...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Tétrapyrroles › Corrinoïdes › Vitamine B12 › Circulating levels of micronutrients and risk...
questionsmedicales.fr › Glucides › Oses acides › Acide ascorbique › Circulating levels of micronutrients and risk...