Extranodal natural killer/T-cell lymphoma nasal type in a western population: Molecular profiling identifies new therapeutic targets.

Humans Herpesvirus 4, Human / genetics Epstein-Barr Virus Infections / complications Lymphoma, Extranodal NK-T-Cell / therapy Mutation Killer Cells, Natural / pathology

Journal

American journal of hematology
ISSN: 1096-8652
Titre abrégé: Am J Hematol
Pays: United States
ID NLM: 7610369

Informations de publication

Date de publication:
06 2023
Historique:
revised: 13 02 2023
received: 16 11 2022
accepted: 02 03 2023
medline: 15 5 2023
pubmed: 8 3 2023
entrez: 7 3 2023
Statut: ppublish

Résumé

(A) Correlation matrix of unsupervised co-regulated genes, based on the 208 genes included in the NanoString platform. Some of the clusters of co-regulated genes corresponded to the following: Inflammatory cells; Epstein-Barr virus; B-cells; Cytotoxic T-cells; T-cells; and Proliferation. (B) Analysis of genomic alterations by targeted sequencing. Distribution of mutations in the 62 analyzed genes. Rows correspond to sequenced genes, columns represent individual patients. Color coding: green, missense; blue, synonymous; pink, frameshift; violet, Indel; red, stop gained; yellow, UTR.

Identifiants

DOI: 10.1002/ajh.26904 PMID: 36882876
pubmed: 36882876
doi: 10.1002/ajh.26904
doi:

Types de publication

Letter Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

E134-E138

Informations de copyright

© 2023 Wiley Periodicals LLC.

Auteurs

Eva Gonzalez Barca (E)

Hematology Department, Institut Català d'Oncologia Hospitalet, Hospital Duran i Reynals, IDIBELL, Universitat de Barcelona, Barcelona, Spain.
ORCID: 0000-0002-1323-1508

Laura Tomás-Roca (L)

Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.

Anna Esteve (A)

Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Medical Oncology Department, B-ARGO Badalona, Catalan Institute of Oncology, Barcelona, Spain.

Marta Rodriguez (M)

Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.

Lucía Gato (L)

Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.

Ruth Alonso-Alonso (R)

Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.

Alejandro Martin Garcia-Sancho (A)

Hematology Department, Hospital Clínico Universitario de Salamanca (CAUSA/IBSAL), Salamanca, Spain.

Raul Cordoba (R)

Hematology Department, Fundación Jiménez Díaz, Madrid, Spain.

Anna Monter-Rovira (A)

Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Mariana Bastos-Oreiro (M)

Hematology Department, Gregorio Marañon General University Hospital, Madrid, Spain.

Juan Miguel Bergua Burgues (JM)

Hematology Department, Hospital San Pedro Alcántara, Caceres, Spain.

Maria Jose Sayas (MJ)

Hematology Department, Hospital Universitario Dr. Peset, Valencia, Spain.

Maria Cruz Viguria Alegria (MC)

Hematology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
ORCID: 0000-0002-6092-5393

Jose Javier Sanchez-Blanco (JJ)

Hematology Department, Hospital Morales Messeguer, Murcia, Spain.

Monica Roig Pellicer (M)

Hematology Department, Hospital La Fe, Valencia, Spain.

Hugo Daniel Luzardo Henriquez (HD)

Hematology Department, Hospital Dr. Negrín, Las Palmas de Gran Canaria, Spain.

Raquel de Oña (R)

Hematology Department, MD Anderson Cancer Center, Madrid, Spain.

Maria Elena Cabezudo (ME)

Hematology Department, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain.

Maria Stefania Infante (MS)

Hematology Department, Hospital Infanta Leonor, Madrid, Spain.
ORCID: 0000-0003-0096-9359

José Antonio Queizán Hernández (JA)

Hematology Department, Hospital General de Segovia, Segovia, Spain.

Rebeca Sanz-Pamplona (R)

Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, Barcelona, Spain.

Oscar Blanco (O)

Pathology Department, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.

Ana Mozos (A)

Pathology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Fina Climent (F)

Pathology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet De Llobregat, Barcelona, Spain.

Miguel Angel Piris (MA)

Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Extranodal natural killer/T-cell lymphoma...
questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Gammaherpesvirinae › Lymphocryptovirus › Herpèsvirus humain de type 4 › Extranodal natural killer/T-cell lymphoma...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus oncogènes › Infections à virus Epstein-Barr › Extranodal natural killer/T-cell lymphoma...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Lymphome T-NK extraganglionnaire › Extranodal natural killer/T-cell lymphoma...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Extranodal natural killer/T-cell lymphoma...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › Extranodal natural killer/T-cell lymphoma...