Iron nitroprusside as a chemodynamic agent and inducer of ferroptosis for ovarian cancer therapy.

Animals Mice Female Humans Nitroprusside Iron Ferroptosis Hydrogen Peroxide Reactive Oxygen Species Ovarian Neoplasms / drug therapy

Journal

Journal of materials chemistry. B
ISSN: 2050-7518
Titre abrégé: J Mater Chem B
Pays: England
ID NLM: 101598493

Informations de publication

Date de publication:
05 04 2023
Historique:
medline: 6 4 2023
pubmed: 9 3 2023
entrez: 8 3 2023
Statut: epublish

Résumé

ChemoDynamic Therapy (CDT) is a powerful therapeutic modality using Fenton/Fenton-like reactions to produce oxidative stress for cancer treatment. However, the insufficient amount of catalyst ions and ROS scavenging activity of glutathione peroxidase (GPX4) limit the application of this approach. Therefore, a tailored strategy to regulate the Fenton reaction more efficiently (utilizing dual metal cations) and inhibit the GPX4 activity, is in great demand. Herein, a CDT system is based on dual (Fe

Identifiants

DOI: 10.1039/d2tb02691k PMID: 36883303
pubmed: 36883303
doi: 10.1039/d2tb02691k
doi:

Substances chimiques

Nitroprusside 169D1260KM
Iron E1UOL152H7
Hydrogen Peroxide BBX060AN9V
Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3124-3135

Auteurs

Kanwal Asif (K)

Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, 30172, Venice, Italy. muhammad.adeel@unive.it.
Pathology Unit, Centro di Riferimento Oncologico di Aviano (C.R.O.) IRCCS, 33081, Aviano, Italy.
ORCID: 0000-0001-6923-2019

Muhammad Adeel (M)

Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, 30172, Venice, Italy. muhammad.adeel@unive.it.
Pathology Unit, Centro di Riferimento Oncologico di Aviano (C.R.O.) IRCCS, 33081, Aviano, Italy.

Md Mahbubur Rahman (MM)

Department of Applied Chemistry, Konkuk University, Chungju 27478, Republic of Korea. mahbub1982@kku.ac.kr.
ORCID: 0000-0003-0012-5324

Isabella Caligiuri (I)

Pathology Unit, Centro di Riferimento Oncologico di Aviano (C.R.O.) IRCCS, 33081, Aviano, Italy.

Tiziana Perin (T)

Pathology Unit, Centro di Riferimento Oncologico di Aviano (C.R.O.) IRCCS, 33081, Aviano, Italy.

Maja Cemazar (M)

Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska cesta 2, SI-1000 Ljubljana, Slovenia.

Vincenzo Canzonieri (V)

Pathology Unit, Centro di Riferimento Oncologico di Aviano (C.R.O.) IRCCS, 33081, Aviano, Italy.
Department of Medical, Surgical and Health Sciences, University of Trieste, 34149, Trieste, Italy.
ORCID: 0000-0001-6010-0976

Flavio Rizzolio (F)

Department of Molecular Sciences and Nanosystems, Ca' Foscari University of Venice, 30172, Venice, Italy. muhammad.adeel@unive.it.
Pathology Unit, Centro di Riferimento Oncologico di Aviano (C.R.O.) IRCCS, 33081, Aviano, Italy.
ORCID: 0000-0002-3400-4363

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Iron nitroprusside as a chemodynamic agent and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Iron nitroprusside as a chemodynamic agent and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Iron nitroprusside as a chemodynamic agent and...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'azote › Acide cyanhydrique › Cyanures › Hexacyanoferrates III › Nitroprussiate › Iron nitroprusside as a chemodynamic agent and...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Iron nitroprusside as a chemodynamic agent and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Ferroptose › Iron nitroprusside as a chemodynamic agent and...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Iron nitroprusside as a chemodynamic agent and...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Iron nitroprusside as a chemodynamic agent and...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Iron nitroprusside as a chemodynamic agent and...