Transcriptomic analysis of the Non-Obstructive Azoospermia (NOA) to address gene expression regulation in human testis.
RNA-seq
Spermatogenesis
gene expression regulation
male infertility
molecular interactions
non-obstructive Azoospermia
regulatory network
transcription factors
transcription regulation
transcriptomics
Journal
Systems biology in reproductive medicine
ISSN: 1939-6376
Titre abrégé: Syst Biol Reprod Med
Pays: England
ID NLM: 101464963
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
medline:
15
5
2023
pubmed:
9
3
2023
entrez:
8
3
2023
Statut:
ppublish
Résumé
There is a need to understand the molecular basis of testes under Non-Obstructive Azoospermia (NOA), a state of failed spermatogenesis. There has been a lack of attention to the transcriptome at the level of alternatively spliced mRNAs (iso-mRNAs) and the mechanism of gene expression regulation. Hence, we aimed to establish a reliable iso-mRNA profile of NOA-testes, and explore molecular mechanisms - especially those related to gene expression regulation. We sequenced mRNAs from testicular samples of donors with complete spermatogenesis (control samples) and a failure of spermatogenesis (NOA samples). We identified differentially expressed genes and their iso-mRNAs
Identifiants
pubmed: 36883778
doi: 10.1080/19396368.2023.2176268
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM