Anionic polysaccharides for stabilization and sustained release of antimicrobial peptides.
Controlled release
Daptomycin
Peptide stability
Polysaccharide hydrogels
Staphylococcal infections
Vancomycin
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
05 Apr 2023
05 Apr 2023
Historique:
received:
13
12
2022
revised:
27
02
2023
accepted:
01
03
2023
medline:
4
4
2023
pubmed:
9
3
2023
entrez:
8
3
2023
Statut:
ppublish
Résumé
Chemical and enzymatic in vivo degradation of antimicrobial peptides represents a major challenge for their therapeutic use to treat bacterial infections. In this work, anionic polysaccharides were investigated for their ability to increase the chemical stability and achieve sustained release of such peptides. The investigated formulations comprised a combination of antimicrobial peptides (vancomycin (VAN) and daptomycin (DAP)) and anionic polysaccharides (xanthan gum (XA), hyaluronic acid (HA), propylene glycol alginate (PGA) and alginic acid (ALG)). VAN dissolved in buffer of pH 7.4 and incubated at 37 °C showed first order degradation kinetics with a reaction rate constant k
Identifiants
pubmed: 36889417
pii: S0378-5173(23)00218-1
doi: 10.1016/j.ijpharm.2023.122798
pii:
doi:
Substances chimiques
Delayed-Action Preparations
0
Antimicrobial Peptides
0
Vancomycin
6Q205EH1VU
Daptomycin
NWQ5N31VKK
Polysaccharides
0
Hydrogels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
122798Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.