Risk Factors and Age-Related Patterns of Asthma-Like Symptoms in Early Childhood.
Asthma
Child
Respiratory pattern
Respiratory symptoms
Risk Factors
Wheeze
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
12
08
2022
revised:
08
01
2023
accepted:
21
02
2023
medline:
12
6
2023
pubmed:
9
3
2023
entrez:
8
3
2023
Statut:
ppublish
Résumé
Episodes of asthma-like symptoms in young children are common, but little is known about risk factors and their patterns for the daily symptom burden. We investigated a variety of possible risk factors and their age-related impact on the number of asthma-like episodes during age 0 to 3 years. The study population included 700 children from the Copenhagen Prospective Studies on Asthma in Childhood Diary data were available in 662 children. Male sex, maternal asthma, low birth weight, maternal antibiotic use, high asthma exacerbation polygenic risk score, and high airway immune score were associated with a higher number of episodes in a multivariable analysis. Maternal asthma, preterm birth, caesarean section, and low birth weight showed an increasing impact with age, whereas sibling(s) at birth showed a decreased association with age. The remaining risk factors had a stable pattern during age 0 to 3 years. For every additional clinical risk factor (male sex, low birth weight, and maternal asthma) a child had, we found 34% more episodes (incidence rate ratio: 1.34, 95% confidence interval: 1.21-1.48; P < .001). Using unique day-to-day diary recordings, we identified risk factors for the burden of asthma-like symptoms in the first 3 years of life and described their unique age-related patterns. This provides novel insight into the origin of asthma-like symptoms in early childhood that potentially pave a path for personalized prognostics and treatment.
Sections du résumé
BACKGROUND
Episodes of asthma-like symptoms in young children are common, but little is known about risk factors and their patterns for the daily symptom burden.
OBJECTIVE
We investigated a variety of possible risk factors and their age-related impact on the number of asthma-like episodes during age 0 to 3 years.
METHODS
The study population included 700 children from the Copenhagen Prospective Studies on Asthma in Childhood
RESULTS
Diary data were available in 662 children. Male sex, maternal asthma, low birth weight, maternal antibiotic use, high asthma exacerbation polygenic risk score, and high airway immune score were associated with a higher number of episodes in a multivariable analysis. Maternal asthma, preterm birth, caesarean section, and low birth weight showed an increasing impact with age, whereas sibling(s) at birth showed a decreased association with age. The remaining risk factors had a stable pattern during age 0 to 3 years. For every additional clinical risk factor (male sex, low birth weight, and maternal asthma) a child had, we found 34% more episodes (incidence rate ratio: 1.34, 95% confidence interval: 1.21-1.48; P < .001).
CONCLUSION
Using unique day-to-day diary recordings, we identified risk factors for the burden of asthma-like symptoms in the first 3 years of life and described their unique age-related patterns. This provides novel insight into the origin of asthma-like symptoms in early childhood that potentially pave a path for personalized prognostics and treatment.
Identifiants
pubmed: 36889671
pii: S2213-2198(23)00236-2
doi: 10.1016/j.jaip.2023.02.031
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1773-1784.e10Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.